1 keywords

CATH Domain 2abjG01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.470 D-amino Acid Aminotransferase; Chain A, domain 1
Homologous Superfamily 3.30.470.10 Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain

Domain Context

CATH Clusters

Superfamily 3.30.470.10
Functional Family Branched-chain-amino-acid aminotransferase

Enzyme Information

2.6.1.42
Branched-chain-amino-acid transaminase.
based on mapping to UniProt P54687
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
-!- Also acts on L-isoleucine and L-valine. -!- Different from EC 2.6.1.66.

UniProtKB Entries (1)

P54687
BCAT1_HUMAN
Homo sapiens
Branched-chain-amino-acid aminotransferase, cytosolic

PDB Structure

PDB 2ABJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.
Hu, L.Y., Boxer, P.A., Kesten, S.R., Lei, H.J., Wustrow, D.J., Moreland, D.W., Zhang, L., Ahn, K., Ryder, T.R., Liu, X., Rubin, J.R., Fahnoe, K., Carroll, R.T., Dutta, S., Fahnoe, D.C., Probert, A.W., Roof, R.L., Rafferty, M.F., Kostlan, C.R., Scholten, J.D., Hood, M., Ren, X.D., Schielke, G.P., Su, T.Z., Taylor, C.P., Mistry, A., McConnell, P., Hasemann, C., Ohren, J.
Bioorg.Med.Chem.Lett.