CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.274 | Enzyme I; Chain A, domain 2 | |
1.10.274.100 | RNA polymerase Rpb1, domain 3 |
Domain Context
CATH Clusters
Superfamily | RNA polymerase Rpb1, domain 3 |
Functional Family | DNA-directed RNA polymerase subunit |
Enzyme Information
2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P04050
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
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UniProtKB Entries (1)
P16370 |
RPB3_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase II subunit RPB3
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PDB Structure
PDB | 1TWG |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
Cell(Cambridge,Mass.)
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