CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.2300 | Response regulator |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.2300 |
| Functional Family | Galactitol-specific phosphotransferase enzyme IIB component |
Enzyme Information
| 2.7.1.200 |
Protein-N(pi)-phosphohistidine--galactitol phosphotransferase.
based on mapping to UniProt P0A435
[Protein]-N(pi)-phospho-L-histidine + galactitol(Side 1) = [protein]-L- histidine + galactitol 1-phosphate(Side 2).
-!- This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). -!- The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. -!- The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9. -!- Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. -!- The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate. -!- Formerly EC 2.7.1.69.
|
UniProtKB Entries (1)
| P0A435 |
PTKB_ECOL6
Escherichia coli CFT073
PTS system galactitol-specific EIIB component
|
PDB Structure
| PDB | 1TVM |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
NMR structure of the enzyme GatB of the galactitol-specific phosphoenolpyruvate-dependent phosphotransferase system and its interaction with GatA.
Protein Sci.
|