CATH Domain 1sm8A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.40	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A
	2.70.40.10	Deoxyuridine triphosphatase (dUTPase)

Domain Context

CATH Clusters

Superfamily	2.70.40.10
Functional Family	Deoxyuridine 5'-triphosphate nucleotidohydrolase

Enzyme Information

3.6.1.23

dUTP diphosphatase.

based on mapping to UniProt P9WNS5

dUTP + H(2)O = dUMP + diphosphate.

UniProtKB Entries (1)

DUT_MYCTU

Mycobacterium tuberculosis H37Rv

Deoxyuridine 5'-triphosphate nucleotidohydrolase

PDB Structure

PDB	1SM8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. Chan, S., Segelke, B., Lekin, T., Krupka, H., Cho, U.S., Kim, M.-Y., So, M., Kim, C.-Y., Naranjo, C.M., Rogers, Y.C., Park, M.S., Waldo, G.S., Pashkov, I., Cascio, D., Perry, J.L., Sawaya, M.R. J.Mol.Biol.