CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.390.30
Functional Family Glutathione reductase

Enzyme Information

1.8.1.7
Glutathione-disulfide reductase.
based on mapping to UniProt P00390
2 glutathione + NADP(+) = glutathione disulfide + NADPH.
-!- Activity is dependent on a redox-active disulfide in each of the active centers. -!- Formerly EC 1.6.4.2.

UniProtKB Entries (1)

P00390
GSHR_HUMAN
Homo sapiens
Glutathione reductase, mitochondrial

PDB Structure

PDB 1GRE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 A resolution.
Karplus, P.A., Schulz, G.E.
J.Mol.Biol.