CATH Classification
Domain Context
CATH Clusters
| Superfamily | Phosphatidylinositol 3-kinase, accessory domain (PIK) |
| Functional Family | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
Enzyme Information
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O02697
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
| 2.7.1.153 |
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt O02697
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
|
UniProtKB Entries (1)
| O02697 |
PK3CG_PIG
Sus scrofa
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
|
PDB Structure
| PDB | 1E7V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.
Mol.Cell
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