PDB Information

PDB5WAL
MethodX-RAY DIFFRACTION
Host Organismunidentified baculovirus
Gene SourceHomo sapiens
Primary Citation
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Liang, J., Van Abbema, A., Balazs, M., Barrett, K., Berezhkovsky, L., Blair, W.S., Chang, C., Delarosa, D., DeVoss, J., Driscoll, J., Eigenbrot, C., Goodacre, S., Ghilardi, N., MacLeod, C., Johnson, A., Bir Kohli, P., Lai, Y., Lin, Z., Mantik, P., Menghrajani, K., Nguyen, H., Peng, I., Sambrone, A., Shia, S., Smith, J., Sohn, S., Tsui, V., Ultsch, M., Williams, K., Wu, L.C., Yang, W., Zhang, B., Magnuson, S.
Bioorg. Med. Chem. Lett.
HeaderTransferase/Transferase Inhibitor
Released2017-06-26
Resolution2.450
CATH Insert Date14 Nov, 2017

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5walA01 10 Dec, 2017 3.30.200.20 Assigned
5walA02 10 Dec, 2017 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P29597 TYK2_HUMAN Homo sapiens Non-receptor tyrosine-protein kinase TYK2
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