CATH Domain 5walA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P29597

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29597

TYK2_HUMAN

Homo sapiens

Non-receptor tyrosine-protein kinase TYK2

PDB Structure

PDB	5WAL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model. Liang, J., Van Abbema, A., Balazs, M., Barrett, K., Berezhkovsky, L., Blair, W.S., Chang, C., Delarosa, D., DeVoss, J., Driscoll, J., Eigenbrot, C., Goodacre, S., Ghilardi, N., MacLeod, C., Johnson, A., Bir Kohli, P., Lai, Y., Lin, Z., Mantik, P., Menghrajani, K., Nguyen, H., Peng, I., Sambrone, A., Shia, S., Smith, J., Sohn, S., Tsui, V., Ultsch, M., Williams, K., Wu, L.C., Yang, W., Zhang, B., Magnuson, S. Bioorg. Med. Chem. Lett.