PDB 5uz0

PDB Links
Overview

PDB Information

PDB	5UZ0
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. Fales, K.R., Njoroge, F.G., Brooks, H.B., Thibodeaux, S., Torrado, A., Si, C., Toth, J.L., Mc Cowan, J.R., Roth, K.D., Thrasher, K.J., Frimpong, K., Lee, M.R., Dally, R.D., Shepherd, T.A., Durham, T.B., Margolis, B.J., Wu, Z., Wang, Y., Atwell, S., Wang, J., Hui, Y.H., Meier, T.I., Konicek, S.A., Geeganage, S. J. Med. Chem.
Header	Transferase, Hydrolase
Released	2017-02-24
Resolution	1.790
CATH Insert Date	03 Jun, 2018

PDB Images (21)

5uz0

PDB 5uz0

5uz0A

PDB Chain 5uz0A

5uz0B

PDB Chain 5uz0B

5uz0C

PDB Chain 5uz0C

5uz0D

PDB Chain 5uz0D

5uz0A01

CATH Domain 5uz0A01

5uz0A02

CATH Domain 5uz0A02

5uz0A03

CATH Domain 5uz0A03

5uz0A04

CATH Domain 5uz0A04

5uz0B01

CATH Domain 5uz0B01

5uz0B02

CATH Domain 5uz0B02

5uz0B03

CATH Domain 5uz0B03

5uz0B04

CATH Domain 5uz0B04

5uz0C01

CATH Domain 5uz0C01

5uz0C02

CATH Domain 5uz0C02

5uz0C03

CATH Domain 5uz0C03

5uz0C04

CATH Domain 5uz0C04

5uz0D01

CATH Domain 5uz0D01

5uz0D02

CATH Domain 5uz0D02

5uz0D03

CATH Domain 5uz0D03

5uz0D04

CATH Domain 5uz0D04

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	03 Jun, 2018	Chopped
B	03 Jun, 2018	Chopped
C	03 Jun, 2018	Chopped
D	03 Jun, 2018	Chopped

CATH Domains (16)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5uz0A01	28 Jun, 2018	3.40.50.1380	Assigned
5uz0A02	28 Jun, 2018	3.40.140.20	Assigned
5uz0A03	28 Jun, 2018	3.40.140.20	Assigned
5uz0A04	28 Jun, 2018	1.10.287.440	Assigned
5uz0B01	28 Jun, 2018	3.40.50.1380	Assigned
5uz0B02	28 Jun, 2018	3.40.140.20	Assigned
5uz0B03	28 Jun, 2018	3.40.140.20	Assigned
5uz0B04	28 Jun, 2018	1.10.287.440	Assigned
5uz0C01	28 Jun, 2018	3.40.50.1380	Assigned
5uz0C02	28 Jun, 2018	3.40.140.20	Assigned
5uz0C03	28 Jun, 2018	3.40.140.20	Assigned
5uz0C04	28 Jun, 2018	1.10.287.440	Assigned
5uz0D01	28 Jun, 2018	3.40.50.1380	Assigned
5uz0D02	28 Jun, 2018	3.40.140.20	Assigned
5uz0D03	28 Jun, 2018	3.40.140.20	Assigned
5uz0D04	28 Jun, 2018	1.10.287.440	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
P31939	PUR9_HUMAN	Homo sapiens	Bifunctional purine biosynthesis protein PURH
P31939	PUR9_HUMAN	Homo sapiens	Bifunctional purine biosynthesis protein PURH
P31939	PUR9_HUMAN	Homo sapiens	Bifunctional purine biosynthesis protein PURH
P31939	PUR9_HUMAN	Homo sapiens	Bifunctional purine biosynthesis protein PURH