CATH Domain 5uz0A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1380	Methylglyoxal synthase-like domain

Domain Context

CATH Clusters

Superfamily	Methylglyoxal synthase-like domain
Functional Family

Enzyme Information

2.1.2.3	Phosphoribosylaminoimidazolecarboxamide formyltransferase. based on mapping to UniProt P31939 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
3.5.4.10	IMP cyclohydrolase. based on mapping to UniProt P31939 IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

PUR9_HUMAN

Homo sapiens

Bifunctional purine biosynthesis protein PURH

PDB Structure

PDB	5UZ0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. Fales, K.R., Njoroge, F.G., Brooks, H.B., Thibodeaux, S., Torrado, A., Si, C., Toth, J.L., Mc Cowan, J.R., Roth, K.D., Thrasher, K.J., Frimpong, K., Lee, M.R., Dally, R.D., Shepherd, T.A., Durham, T.B., Margolis, B.J., Wu, Z., Wang, Y., Atwell, S., Wang, J., Hui, Y.H., Meier, T.I., Konicek, S.A., Geeganage, S. J. Med. Chem.