PDB 5u8a

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Overview

PDB Information

PDB	5U8A
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Curtin, M.L., Pliushchev, M.A., Li, H.Q., Torrent, M., Dietrich, J.D., Jakob, C.G., Zhu, H., Zhao, H., Wang, Y., Ji, Z., Clark, R.F., Sarris, K.A., Selvaraju, S., Shaw, B., Algire, M.A., He, Y., Richardson, P.L., Sweis, R.F., Sun, C., Chiang, G.G., Michaelides, M.R. Bioorg. Med. Chem. Lett.
Header	Protein Binding/Inhibitor
Released	2016-12-14
Resolution	1.450
CATH Insert Date	07 May, 2017

PDB Images (3)

Image of CATH 5u8a

5u8a

PDB 5u8a

Image of CATH 5u8aA

5u8aA

PDB Chain 5u8aA

Image of CATH 5u8aA00

5u8aA00

CATH Domain 5u8aA00

PDB Prints

PDB Chains (1)

Chain ID	Date inserted into CATH	CATH Status
A	08 May, 2017	Chopped

CATH Domains (1)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5u8aA00	14 Dec, 2017	2.130.10.10	Assigned

UniProtKB Entries (1)

Accession	Gene ID	Taxon	Description
O75530	EED_HUMAN	Homo sapiens	Polycomb protein EED