CATH Classification

Domain Context

CATH Clusters

Superfamily YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family Polycomb protein eed

Enzyme Information

UniProtKB Entries (1)

O75530
EED_HUMAN
Homo sapiens
Polycomb protein EED

PDB Structure

PDB 5U8A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.
Curtin, M.L., Pliushchev, M.A., Li, H.Q., Torrent, M., Dietrich, J.D., Jakob, C.G., Zhu, H., Zhao, H., Wang, Y., Ji, Z., Clark, R.F., Sarris, K.A., Selvaraju, S., Shaw, B., Algire, M.A., He, Y., Richardson, P.L., Sweis, R.F., Sun, C., Chiang, G.G., Michaelides, M.R.
Bioorg. Med. Chem. Lett.