PDB Information

PDB5TFT
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli DH5[alpha]
Gene SourceHomo sapiens
Primary Citation
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
Butler, C.R., Ogilvie, K., Martinez-Alsina, L., Barreiro, G., Beck, E.M., Nolan, C.E., Atchison, K., Benvenuti, E., Buzon, L., Doran, S., Gonzales, C., Helal, C.J., Hou, X., Hsu, M.H., Johnson, E.F., Lapham, K., Lanyon, L., Parris, K., O'Neill, B.T., Riddell, D., Robshaw, A., Vajdos, F., Brodney, M.A.
J. Med. Chem.
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2016-09-26
Resolution2.710
CATH Insert Date07 May, 2017

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped
C 08 May, 2017 Chopped
D 08 May, 2017 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5tftA00 21 May, 2017 1.10.630.10 Assigned
5tftB00 21 May, 2017 1.10.630.10 Assigned
5tftC00 21 May, 2017 1.10.630.10 Assigned
5tftD00 21 May, 2017 1.10.630.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P10635 CP2D6_HUMAN Homo sapiens Cytochrome P450 2D6
P10635 CP2D6_HUMAN Homo sapiens Cytochrome P450 2D6
P10635 CP2D6_HUMAN Homo sapiens Cytochrome P450 2D6
P10635 CP2D6_HUMAN Homo sapiens Cytochrome P450 2D6