CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family cytochrome P450 2D15 isoform X1

Enzyme Information

1.14.14.1
Unspecific monooxygenase.
based on mapping to UniProt P10635
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
-!- Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. -!- Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH. -!- Some of the reactions attributed to EC 1.14.15.3 belong here. -!- Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.

UniProtKB Entries (1)

P10635
CP2D6_HUMAN
Homo sapiens
Cytochrome P450 2D6

PDB Structure

PDB 5TFT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
Butler, C.R., Ogilvie, K., Martinez-Alsina, L., Barreiro, G., Beck, E.M., Nolan, C.E., Atchison, K., Benvenuti, E., Buzon, L., Doran, S., Gonzales, C., Helal, C.J., Hou, X., Hsu, M.H., Johnson, E.F., Lapham, K., Lanyon, L., Parris, K., O'Neill, B.T., Riddell, D., Robshaw, A., Vajdos, F., Brodney, M.A.
J. Med. Chem.