PDB 5kpl

PDB Information

PDB5KPL
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Wagner, F.F., Benajiba, L., Campbell, A.J., Weiwer, M., Sacher, J.R., Gale, J.P., Ross, L., Puissant, A., Alexe, G., Conway, A., Back, M., Pikman, Y., Galinsky, I., DeAngelo, D.J., Stone, R.M., Kaya, T., Shi, X., Robers, M.B., Machleidt, T., Wilkinson, J., Hermine, O., Kung, A., Stein, A.J., Lakshminarasimhan, D., Hemann, M.T., Scolnick, E., Zhang, Y.L., Pan, J.Q., Stegmaier, K., Holson, E.B.
Sci Transl Med
HeaderTransferase/Transferase Inhibitor
Released2016-07-04
Resolution2.600
CATH Insert Date03 Jun, 2018

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped
B 03 Jun, 2018 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5kplA01 27 Jun, 2018 3.30.200.20 Assigned
5kplA02 27 Jun, 2018 1.10.510.10 Assigned
5kplB01 27 Jun, 2018 3.30.200.20 Assigned
5kplB02 27 Jun, 2018 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P49841 GSK3B_HUMAN Homo sapiens Glycogen synthase kinase-3 beta
P49841 GSK3B_HUMAN Homo sapiens Glycogen synthase kinase-3 beta