CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Glycogen synthase kinase-3 beta

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49841
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26
[Tau protein] kinase.
based on mapping to UniProt P49841
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (1)

P49841
GSK3B_HUMAN
Homo sapiens
Glycogen synthase kinase-3 beta

PDB Structure

PDB 5KPL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Wagner, F.F., Benajiba, L., Campbell, A.J., Weiwer, M., Sacher, J.R., Gale, J.P., Ross, L., Puissant, A., Alexe, G., Conway, A., Back, M., Pikman, Y., Galinsky, I., DeAngelo, D.J., Stone, R.M., Kaya, T., Shi, X., Robers, M.B., Machleidt, T., Wilkinson, J., Hermine, O., Kung, A., Stein, A.J., Lakshminarasimhan, D., Hemann, M.T., Scolnick, E., Zhang, Y.L., Pan, J.Q., Stegmaier, K., Holson, E.B.
Sci Transl Med
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