PDB 4zbi

PDB Links
Overview

PDB Information

PDB	4ZBI
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design. Burke, J.P., Bian, Z., Shaw, S., Zhao, B., Goodwin, C.M., Belmar, J., Browning, C.F., Vigil, D., Friberg, A., Camper, D.V., Rossanese, O.W., Lee, T., Olejniczak, E.T., Fesik, S.W. J.Med.Chem.
Header	Apoptosis/Apoptosis Inhibitor
Released	2015-04-14
Resolution	2.500
CATH Insert Date	28 Jun, 2015

PDB Images (25)

4zbi

PDB 4zbi

4zbiA

PDB Chain 4zbiA

4zbiB

PDB Chain 4zbiB

4zbiC

PDB Chain 4zbiC

4zbiD

PDB Chain 4zbiD

4zbiE

PDB Chain 4zbiE

4zbiF

PDB Chain 4zbiF

4zbiG

PDB Chain 4zbiG

4zbiH

PDB Chain 4zbiH

4zbiI

PDB Chain 4zbiI

4zbiJ

PDB Chain 4zbiJ

4zbiK

PDB Chain 4zbiK

4zbiL

PDB Chain 4zbiL

4zbiA01

CATH Domain 4zbiA01

4zbiB01

CATH Domain 4zbiB01

4zbiC01

CATH Domain 4zbiC01

4zbiD01

CATH Domain 4zbiD01

4zbiE01

CATH Domain 4zbiE01

4zbiF01

CATH Domain 4zbiF01

4zbiG01

CATH Domain 4zbiG01

4zbiH01

CATH Domain 4zbiH01

4zbiI01

CATH Domain 4zbiI01

4zbiJ01

CATH Domain 4zbiJ01

4zbiK01

CATH Domain 4zbiK01

4zbiL01

CATH Domain 4zbiL01

PDB Prints

PDB Chains (12)

Chain ID	Date inserted into CATH	CATH Status
A	29 Jun, 2015	Chopped
B	29 Jun, 2015	Chopped
C	29 Jun, 2015	Chopped
D	29 Jun, 2015	Chopped
E	29 Jun, 2015	Chopped
F	29 Jun, 2015	Chopped
G	29 Jun, 2015	Chopped
H	29 Jun, 2015	Chopped
I	29 Jun, 2015	Chopped
J	29 Jun, 2015	Chopped
K	29 Jun, 2015	Chopped
L	29 Jun, 2015	Chopped

CATH Domains (12)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4zbiA01	27 Jul, 2015	1.10.437.10	Assigned
4zbiB01	27 Jul, 2015	1.10.437.10	Assigned
4zbiC01	27 Jul, 2015	1.10.437.10	Assigned
4zbiD01	27 Jul, 2015	1.10.437.10	Assigned
4zbiE01	27 Jul, 2015	1.10.437.10	Assigned
4zbiF01	27 Jul, 2015	1.10.437.10	Assigned
4zbiG01	27 Jul, 2015	1.10.437.10	Assigned
4zbiH01	27 Jul, 2015	1.10.437.10	Assigned
4zbiI01	27 Jul, 2015	1.10.437.10	Assigned
4zbiJ01	27 Jul, 2015	1.10.437.10	Assigned
4zbiK01	27 Jul, 2015	1.10.437.10	Assigned
4zbiL01	27 Jul, 2015	1.10.437.10	Assigned

UniProtKB Entries (12)

Accession	Gene ID	Taxon	Description
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1