1 keywords

CATH Domain 4zbiK01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.437 Apoptosis Regulator Bcl-x
Homologous Superfamily 1.10.437.10 Blc2-like

Domain Context

CATH Clusters

Superfamily Blc2-like
Functional Family Induced myeloid leukemia cell differentiation protein Mcl-1

Enzyme Information

UniProtKB Entries (1)

Q07820
MCL1_HUMAN
Homo sapiens
Induced myeloid leukemia cell differentiation protein Mcl-1

PDB Structure

PDB 4ZBI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design.
Burke, J.P., Bian, Z., Shaw, S., Zhao, B., Goodwin, C.M., Belmar, J., Browning, C.F., Vigil, D., Friberg, A., Camper, D.V., Rossanese, O.W., Lee, T., Olejniczak, E.T., Fesik, S.W.
J.Med.Chem.