PDB 4yp8

PDB Information

PDB4YP8
MethodX-RAY DIFFRACTION
Host OrganismSPODOPTERA FRUGIPERDA
Gene SourceHomo sapiens
Primary Citation
Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation.
McElroy, W.T., Tan, Z., Ho, G., Paliwal, S., Li, G., Seganish, W.M., Tulshian, D., Tata, J., Fischmann, T.O., Sondey, C., Bian, H., Bober, L., Jackson, J., Garlisi, C.G., Devito, K., Fossetta, J., Lundell, D., Niu, X.
Acs Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2015-03-12
Resolution2.640
CATH Insert Date28 Jun, 2015

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 29 Jun, 2015 Chopped
B 29 Jun, 2015 Chopped
C 29 Jun, 2015 Chopped
D 29 Jun, 2015 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4yp8A01 22 Jul, 2015 3.30.200.20 Assigned
4yp8A02 22 Jul, 2015 1.10.510.10 Assigned
4yp8B01 22 Jul, 2015 3.30.200.20 Assigned
4yp8B02 22 Jul, 2015 1.10.510.10 Assigned
4yp8C01 22 Jul, 2015 3.30.200.20 Assigned
4yp8C02 22 Jul, 2015 1.10.510.10 Assigned
4yp8D01 22 Jul, 2015 3.30.200.20 Assigned
4yp8D02 22 Jul, 2015 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4