CATH Domain 4yp8B02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Interleukin-1 receptor-associated kinase 4

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q9NWZ3

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9NWZ3

IRAK4_HUMAN

Homo sapiens

Interleukin-1 receptor-associated kinase 4

PDB Structure

PDB	4YP8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation. McElroy, W.T., Tan, Z., Ho, G., Paliwal, S., Li, G., Seganish, W.M., Tulshian, D., Tata, J., Fischmann, T.O., Sondey, C., Bian, H., Bober, L., Jackson, J., Garlisi, C.G., Devito, K., Fossetta, J., Lundell, D., Niu, X. Acs Med.Chem.Lett.