PDB 4w9l
PDB Information
| PDB | 4W9L |
| Method | X-RAY DIFFRACTION |
| Host Organism | Escherichia coli BL21(DE3) |
| Gene Source | Homo sapiens |
| Primary Citation | Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
J.Med.Chem.
|
| Header | Ligase |
| Released | 2014-08-27 |
| Resolution | 2.200 |
| CATH Insert Date | 14 Sep, 2014 |
PDB Images (29)
4w9l
PDB 4w9l
4w9lA
PDB Chain 4w9lA
4w9lB
PDB Chain 4w9lB
4w9lC
PDB Chain 4w9lC
4w9lD
PDB Chain 4w9lD
4w9lE
PDB Chain 4w9lE
4w9lF
PDB Chain 4w9lF
4w9lG
PDB Chain 4w9lG
4w9lH
PDB Chain 4w9lH
4w9lI
PDB Chain 4w9lI
4w9lJ
PDB Chain 4w9lJ
4w9lK
PDB Chain 4w9lK
4w9lL
PDB Chain 4w9lL
4w9lA00
CATH Domain 4w9lA00
4w9lB00
CATH Domain 4w9lB00
4w9lC01
CATH Domain 4w9lC01
4w9lC02
CATH Domain 4w9lC02
4w9lD00
CATH Domain 4w9lD00
4w9lE00
CATH Domain 4w9lE00
4w9lF01
CATH Domain 4w9lF01
4w9lF02
CATH Domain 4w9lF02
4w9lG00
CATH Domain 4w9lG00
4w9lH00
CATH Domain 4w9lH00
4w9lI01
CATH Domain 4w9lI01
4w9lI02
CATH Domain 4w9lI02
4w9lJ00
CATH Domain 4w9lJ00
4w9lK00
CATH Domain 4w9lK00
4w9lL01
CATH Domain 4w9lL01
4w9lL02
CATH Domain 4w9lL02
PDB Prints
PDB Chains (12)
| Chain ID | Date inserted into CATH | CATH Status |
|---|---|---|
| A | 15 Sep, 2014 | Chopped |
| B | 15 Sep, 2014 | Chopped |
| C | 15 Sep, 2014 | Chopped |
| D | 15 Sep, 2014 | Chopped |
| E | 15 Sep, 2014 | Chopped |
| F | 15 Sep, 2014 | Chopped |
| G | 15 Sep, 2014 | Chopped |
| H | 15 Sep, 2014 | Chopped |
| I | 15 Sep, 2014 | Chopped |
| J | 15 Sep, 2014 | Chopped |
| K | 15 Sep, 2014 | Chopped |
| L | 15 Sep, 2014 | Chopped |
CATH Domains (16)
| Domain ID | Date inserted into CATH | Superfamily | CATH Status |
|---|---|---|---|
| 4w9lA00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9lB00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9lC01 | 17 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9lC02 | 17 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9lD00 | 17 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9lE00 | 17 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9lF01 | 17 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9lF02 | 17 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9lG00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9lH00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9lI01 | 16 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9lI02 | 16 Sep, 2014 | 1.10.750.10 | Assigned |
| 4w9lJ00 | 16 Sep, 2014 | 3.10.20.90 | Assigned |
| 4w9lK00 | 16 Sep, 2014 | 3.30.710.10 | Assigned |
| 4w9lL01 | 17 Sep, 2014 | 2.60.40.780 | Assigned |
| 4w9lL02 | 17 Sep, 2014 | 1.10.750.10 | Assigned |
UniProtKB Entries (12)
| Accession | Gene ID | Taxon | Description |
|---|---|---|---|
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
