CATH Domain 4w9lF02

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.750	Elongin C; Chain C, domain 1
	1.10.750.10	von Hippel-Lindau disease tumour suppressor, alpha domain

Domain Context

CATH Clusters

Superfamily	von Hippel-Lindau disease tumour suppressor, alpha domain
Functional Family	von Hippel-Lindau disease tumor suppressor

Enzyme Information

UniProtKB Entries (1)

ELOC_HUMAN

Homo sapiens

Elongin-C

PDB Structure

PDB	4W9L
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities. Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A. J.Med.Chem.