PDB 4w9i

PDB Information

PDB4W9I
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21(DE3)
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A.
J.Med.Chem.
HeaderLigase
Released2014-08-27
Resolution2.400
CATH Insert Date14 Sep, 2014

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 15 Sep, 2014 Chopped
B 15 Sep, 2014 Chopped
C 15 Sep, 2014 Chopped
D 15 Sep, 2014 Chopped
E 15 Sep, 2014 Chopped
F 15 Sep, 2014 Chopped
G 15 Sep, 2014 Chopped
H 15 Sep, 2014 Chopped
I 15 Sep, 2014 Chopped
J 15 Sep, 2014 Chopped
K 15 Sep, 2014 Chopped
L 15 Sep, 2014 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
4w9iA00 17 Sep, 2014 3.10.20.90 Assigned
4w9iB00 17 Sep, 2014 3.30.710.10 Assigned
4w9iC01 17 Sep, 2014 2.60.40.780 Assigned
4w9iC02 17 Sep, 2014 1.10.750.10 Assigned
4w9iD00 17 Sep, 2014 3.10.20.90 Assigned
4w9iE00 17 Sep, 2014 3.30.710.10 Assigned
4w9iF01 17 Sep, 2014 2.60.40.780 Assigned
4w9iF02 17 Sep, 2014 1.10.750.10 Assigned
4w9iG00 17 Sep, 2014 3.10.20.90 Assigned
4w9iH00 17 Sep, 2014 3.30.710.10 Assigned
4w9iI01 17 Sep, 2014 2.60.40.780 Assigned
4w9iI02 17 Sep, 2014 1.10.750.10 Assigned
4w9iJ00 17 Sep, 2014 3.10.20.90 Assigned
4w9iK00 17 Sep, 2014 3.30.710.10 Assigned
4w9iL01 17 Sep, 2014 2.60.40.780 Assigned
4w9iL02 17 Sep, 2014 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor