CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.750 | Elongin C; Chain C, domain 1 |
|
1.10.750.10 | von Hippel-Lindau disease tumour suppressor, alpha domain |
Domain Context
CATH Clusters
| Superfamily | von Hippel-Lindau disease tumour suppressor, alpha domain |
| Functional Family | von Hippel-Lindau disease tumor suppressor |
Enzyme Information
UniProtKB Entries (1)
| P40337 |
VHL_HUMAN
Homo sapiens
Von Hippel-Lindau disease tumor suppressor
|
PDB Structure
| PDB | 4W9I |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
J.Med.Chem.
|
