PDB 4mib

PDB Information

PDB4MIB
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHepatitis C virus
Primary Citation
Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.
Talamas, F.X., Abbot, S.C., Anand, S., Brameld, K.A., Carter, D.S., Chen, J., Davis, D., de Vicente, J., Fung, A.D., Gong, L., Harris, S.F., Inbar, P., Labadie, S.S., Lee, E.K., Lemoine, R., Le Pogam, S., Leveque, V., Li, J., McIntosh, J., Najera, I., Park, J., Railkar, A., Rajyaguru, S., Sangi, M., Schoenfeld, R.C., Staben, L.R., Tan, Y., Taygerly, J.P., Villasenor, A.G., Weller, P.E.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2013-08-30
Resolution2.300
CATH Insert Date11 May, 2014

PDB Images (11)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 12 May, 2014 Chopped
B 12 May, 2014 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
4mibA01 30 Jun, 2015 Holding pen
4mibA02 30 Jun, 2015 Holding pen
4mibA03 30 Jun, 2015 3.30.70.270 Assigned
4mibA04 30 Jun, 2015 Holding pen
4mibB01 30 Jun, 2015 Holding pen
4mibB02 30 Jun, 2015 Holding pen
4mibB03 30 Jun, 2015 3.30.70.270 Assigned
4mibB04 30 Jun, 2015 Holding pen

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P26663 POLG_HCVBK Hepatitis C virus (isolate BK) Genome polyprotein
P26663 POLG_HCVBK Hepatitis C virus (isolate BK) Genome polyprotein