PDB 4jh0

PDB Links
Overview

PDB Information

PDB	4JH0
Method	X-RAY DIFFRACTION
Host Organism	Komagataella pastoris
Gene Source	Homo sapiens
Primary Citation	Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778). Devasthale, P., Wang, Y., Wang, W., Fevig, J., Feng, J., Wang, A., Harrity, T., Egan, D., Morgan, N., Cap, M., Fura, A., Klei, H.E., Kish, K., Weigelt, C., Sun, L., Levesque, P., Moulin, F., Li, Y.X., Zahler, R., Kirby, M.S., Hamann, L.G. J.Med.Chem.
Header	Hydrolase
Released	2013-03-04
Resolution	2.350
CATH Insert Date	22 Sep, 2013

PDB Images (7)

Image of CATH 4jh0

4jh0

PDB 4jh0

Image of CATH 4jh0A

4jh0A

PDB Chain 4jh0A

Image of CATH 4jh0B

4jh0B

PDB Chain 4jh0B

Image of CATH 4jh0A01

4jh0A01

CATH Domain 4jh0A01

Image of CATH 4jh0A02

4jh0A02

CATH Domain 4jh0A02

Image of CATH 4jh0B01

4jh0B01

CATH Domain 4jh0B01

Image of CATH 4jh0B02

4jh0B02

CATH Domain 4jh0B02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	23 Sep, 2013	Chopped
B	23 Sep, 2013	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4jh0A01	25 Sep, 2013	3.40.50.1820	Assigned
4jh0A02	25 Sep, 2013	2.140.10.30	Assigned
4jh0B01	25 Sep, 2013	3.40.50.1820	Assigned
4jh0B02	25 Sep, 2013	2.140.10.30	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P27487	DPP4_HUMAN	Homo sapiens	Dipeptidyl peptidase 4
P27487	DPP4_HUMAN	Homo sapiens	Dipeptidyl peptidase 4