The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

alpha/beta hydrolase

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Alpha/Beta hydrolase fold, catalytic domain

This superfamily consists of structural domains from hydrolytic enzymes that have an alpha/beta fold. These include: cholinesterases, carboxypeptidases, hydrolases, lipases. The ESTHER database (ESTerases and alpha/beta-Hydrolase Enzymes and Relatives) gathers and annotates all the published information related to gene and protein sequences of this superfamily. Structures and families can be found at: and

The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 strands connected by helices. The enzymes are believed to have diverged from a common ancestor, preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best conserved structural features of the fold. These enzymes have diverged from a common ancestor so as to preserve the arrangement of the catalytic residues, not the binding site. In most of the superfamily members the beta-strands are parallels, but some have an inversion of the first strands, which gives it an antiparallel orientation. The catalytic triad residues are presented on loops. One of these is the nucleophile elbow and is the most conserved feature of the fold. Some other members lack one or all of the catalytic residues. Some members are therefore inactive but others are involved in surface recognition.

Pfam clan [PfamClan:CL0028], Pfam family PFAM:PF00561, INTERPRO:IPR029058,PMID:1409539,PMID:14681380

GO Diversity

Unique GO annotations
1318 Unique GO terms

EC Diversity

Unique EC annotations
130 Unique EC terms

Species Diversity

Unique species annotations
26788 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 3809
Domain clusters (>95% seq id): 456
Domain clusters (>35% seq id): 256
Unique PDBs: 1919
Structural Clusters (5A): 33
Structural Clusters (9A): 17
FunFam Clusters: 1873
Unique EC: 130
Unique GO: 1318
Unique Species: 26788