PDB 4dk5

PDB Information

PDB4DK5
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
Smith, A.L., D'Angelo, N.D., Bo, Y.Y., Booker, S.K., Cee, V.J., Herberich, B., Hong, F.T., Jackson, C.L., Lanman, B.A., Liu, L., Nishimura, N., Pettus, L.H., Reed, A.B., Tadesse, S., Tamayo, N.A., Wurz, R.P., Yang, K., Andrews, K.L., Whittington, D.A., McCarter, J.D., Miguel, T.S., Zalameda, L., Jiang, J., Subramanian, R., Mullady, E.L., Caenepeel, S., Freeman, D.J., Wang, L., Zhang, N., Wu, T., Hughes, P.E., Norman, M.H.
J.Med.Chem.
HeaderTransferase/Inhibitor
Released2012-02-03
Resolution2.950
CATH Insert Date27 May, 2012

PDB Images (7)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 28 May, 2012 Chopped

CATH Domains (5)

Domain ID Date inserted into CATH Superfamily CATH Status
4dk5A01 08 Jun, 2012 3.10.20.90 Assigned
4dk5A02 08 Jun, 2012 2.60.40.150 Assigned
4dk5A03 08 Jun, 2012 1.25.40.70 Assigned
4dk5A04 08 Jun, 2012 3.30.1010.10 Assigned
4dk5A05 08 Jun, 2012 1.10.1070.11 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P48736 PK3CG_HUMAN Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform