CATH Domain 4dk5A05

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1070	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5
	1.10.1070.11	Phosphatidylinositol 3-/4-kinase, catalytic domain

Domain Context

CATH Clusters

Superfamily	Phosphatidylinositol 3-/4-kinase, catalytic domain
Functional Family	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Enzyme Information

2.7.1.153	Phosphatidylinositol-4,5-bisphosphate 3-kinase. based on mapping to UniProt P48736 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. -!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt P48736 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

PK3CG_HUMAN

Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

PDB	4DK5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases. Smith, A.L., D'Angelo, N.D., Bo, Y.Y., Booker, S.K., Cee, V.J., Herberich, B., Hong, F.T., Jackson, C.L., Lanman, B.A., Liu, L., Nishimura, N., Pettus, L.H., Reed, A.B., Tadesse, S., Tamayo, N.A., Wurz, R.P., Yang, K., Andrews, K.L., Whittington, D.A., McCarter, J.D., Miguel, T.S., Zalameda, L., Jiang, J., Subramanian, R., Mullady, E.L., Caenepeel, S., Freeman, D.J., Wang, L., Zhang, N., Wu, T., Hughes, P.E., Norman, M.H. J.Med.Chem.