PDB 3c4e

PDB Information

PDB3C4E
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Tsai, J., Lee, J.T., Wang, W., Zhang, J., Cho, H., Mamo, S., Bremer, R., Gillette, S., Kong, J., Haass, N.K., Sproesser, K., Li, L., Smalley, K.S., Fong, D., Zhu, Y.L., Marimuthu, A., Nguyen, H., Lam, B., Liu, J., Cheung, I., Rice, J., Suzuki, Y., Luu, C., Settachatgul, C., Shellooe, R., Cantwell, J., Kim, S.H., Schlessinger, J., Zhang, K.Y., West, B.L., Powell, B., Habets, G., Zhang, C., Ibrahim, P.N., Hirth, P., Artis, D.R., Herlyn, M., Bollag, G.
Proc.Natl.Acad.Sci.Usa
HeaderTransferase
Released2008-01-29
Resolution1.980
CATH Insert Date28 Feb, 2008

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 28 Feb, 2008 Chopped
B 28 Feb, 2008 Chopped
C 28 Feb, 2008 Chopped
D 28 Feb, 2008 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
3c4eA01 29 Feb, 2008 3.30.200.20 Assigned
3c4eA02 29 Feb, 2008 1.10.510.10 Assigned
3c4eB01 02 Mar, 2008 3.30.200.20 Assigned
3c4eB02 02 Mar, 2008 1.10.510.10 Assigned
3c4eC01 02 Mar, 2008 3.30.200.20 Assigned
3c4eC02 02 Mar, 2008 1.10.510.10 Assigned
3c4eD01 02 Mar, 2008 3.30.200.20 Assigned
3c4eD02 02 Mar, 2008 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P11309 PIM1_HUMAN Homo sapiens Serine/threonine-protein kinase pim-1
P11309 PIM1_HUMAN Homo sapiens Serine/threonine-protein kinase pim-1
P11309 PIM1_HUMAN Homo sapiens Serine/threonine-protein kinase pim-1
P11309 PIM1_HUMAN Homo sapiens Serine/threonine-protein kinase pim-1