CATH Domain 3c4eA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase pim-1

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P11309

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P11309

PIM1_HUMAN

Homo sapiens

Serine/threonine-protein kinase pim-1

PDB Structure

PDB	3C4E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity Tsai, J., Lee, J.T., Wang, W., Zhang, J., Cho, H., Mamo, S., Bremer, R., Gillette, S., Kong, J., Haass, N.K., Sproesser, K., Li, L., Smalley, K.S., Fong, D., Zhu, Y.L., Marimuthu, A., Nguyen, H., Lam, B., Liu, J., Cheung, I., Rice, J., Suzuki, Y., Luu, C., Settachatgul, C., Shellooe, R., Cantwell, J., Kim, S.H., Schlessinger, J., Zhang, K.Y., West, B.L., Powell, B., Habets, G., Zhang, C., Ibrahim, P.N., Hirth, P., Artis, D.R., Herlyn, M., Bollag, G. Proc.Natl.Acad.Sci.Usa