PDB 2wd8

PDB Information

PDB2WD8
MethodX-RAY DIFFRACTION
Host OrganismESCHERICHIA COLI
Gene SourceTRYPANOSOMA BRUCEI BRUCEI
Primary Citation
One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening.
Mpamhanga, C.P., Spinks, D., Tulloch, L.B., Shanks, E.J., Robinson, D.A., Collie, I.T., Fairlamb, A.H., Wyatt, P.G., Frearson, J.A., Hunter, W.N., Gilbert, I.H., Brenk, R.
J.Med.Chem.
HeaderOxidoreductase
Released2009-03-20
Resolution2.100
CATH Insert Date16 Aug, 2009

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 16 Aug, 2009 Chopped
B 16 Aug, 2009 Chopped
C 16 Aug, 2009 Chopped
D 16 Aug, 2009 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
2wd8A00 24 Aug, 2009 3.40.50.720 Assigned
2wd8B00 24 Aug, 2009 3.40.50.720 Assigned
2wd8C00 24 Aug, 2009 3.40.50.720 Assigned
2wd8D00 24 Aug, 2009 3.40.50.720 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O76290 O76290_TRYBB Trypanosoma brucei brucei Pteridine reductase
O76290 O76290_TRYBB Trypanosoma brucei brucei Pteridine reductase
O76290 O76290_TRYBB Trypanosoma brucei brucei Pteridine reductase
O76290 O76290_TRYBB Trypanosoma brucei brucei Pteridine reductase