CATH Domain 2wd8B00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Pteridine reductase

Enzyme Information

UniProtKB Entries (1)

O76290_TRYBB

Trypanosoma brucei brucei

Pteridine reductase

PDB Structure

PDB	2WD8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening. Mpamhanga, C.P., Spinks, D., Tulloch, L.B., Shanks, E.J., Robinson, D.A., Collie, I.T., Fairlamb, A.H., Wyatt, P.G., Frearson, J.A., Hunter, W.N., Gilbert, I.H., Brenk, R. J.Med.Chem.