PDB 2i03

PDB Information

PDB2I03
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
Madar, D.J., Kopecka, H., Pireh, D., Yong, H., Pei, Z., Li, X., Wiedeman, P.E., Djuric, S.W., Von Geldern, T.W., Fickes, M.G., Bhagavatula, L., McDermott, T., Wittenberger, S., Richards, S.J., Longenecker, K.L., Stewart, K.D., Lubben, T.H., Ballaron, S.J., Stashko, M.A., Long, M.A., Wells, H., Zinker, B.A., Mika, A.K., Beno, D.W., Kempf-Grote, A.J., Polakowski, J., Segreti, J., Reinhart, G.A., Fryer, R.M., Sham, H.L., Trevillyan, J.M.
J.Med.Chem.
HeaderHydrolase
Released2006-08-09
Resolution2.400
CATH Insert Date07 Jan, 2007

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 07 Jan, 2007 Chopped
B 07 Jan, 2007 Chopped
C 07 Jan, 2007 Chopped
D 07 Jan, 2007 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
2i03A01 08 Jan, 2007 3.40.50.1820 Assigned
2i03A02 08 Jan, 2007 2.140.10.30 Assigned
2i03B01 08 Jan, 2007 3.40.50.1820 Assigned
2i03B02 08 Jan, 2007 2.140.10.30 Assigned
2i03C01 09 Jan, 2007 3.40.50.1820 Assigned
2i03C02 09 Jan, 2007 2.140.10.30 Assigned
2i03D01 09 Jan, 2007 3.40.50.1820 Assigned
2i03D02 09 Jan, 2007 2.140.10.30 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P27487 DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4
P27487 DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4
P27487 DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4
P27487 DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4