The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Glutamine--fructose-6-phosphate aminotransferase [isomerizing]AmidophosphoribosyltransferaseAsparagine synthetase BGamma-glutamyl-hercynylcysteine sulfoxide hydrolaseSC:2Glutamate synthase, large subunitSC:3ATP-dependent protease subunit HslVProteasome subunit beta type-5Proteasome subunit beta type-7Proteasome subunit betaProteasome subunit betaProteasome subunit betaProteasome subunit betaProteasome subunit betaProteasome subunit beta type-6Proteasome subunit betaProteasome subunit betaProteasome subunit betaProteasome subunit betaSC:4Acyl-homoserine lactone acylase PvdQSC:5Proteasome subunit alpha type-3Proteasome subunit alpha typeProteasome subunit alpha type-5Proteasome subunit alpha typeProteasome subunit alpha typeProteasome subunit alpha typeProteasome subunit alphaProteasome subunit alpha typeProteasome subunit alpha type-1Probable proteasome subunit alpha type-7Proteasome subunit alpha type-2Proteasome subunit alpha typeProteasome subunit alpha typeProteasome subunit alpha typeProteasome subunit alpha type-3Proteasome endopeptidase complexProteasome endopeptidase complexProteasome subunit beta type-3Proteasome subunit alpha type-4Proteasome subunit beta type-2Proteasome subunit alpha typeProteasome subunit beta type-4Proteasome subunit beta type-1Proteasome subunit alpha type-6Glucosamine-fructose-6-phosphate aminotransferase, isomerisingProteasome subunit alpha typeglutamine--fructose-6-phosphate aminotransferase [isomerizing] 1Asparagine synthetase [glutamine-hydrolyzing]Proteasome subunit beta type-6Proteasome subunit alpha typeProteasome subunit alpha typeProteasome subunit alpha typeProteasome subunit betaProteasome subunit betaProteasome subunit alpha typeProteasome subunit betaAsparagine synthetase [glutamine-hydrolyzing]Proteasome subunit betaAsparagine synthase (Glutamine-hydrolyzing)Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Glutamate synthase 1 [NADH] chloroplasticGlutamine amidotransferase DUG3AmidophosphoribosyltransferaseProteasome subunit betaAsparagine synthetase 2Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2Proteasome subunit betaNAD(P)H-dependent glutamate synthase, putativeATP-dependent protease subunit ClpQ, putativeProteasome subunit alpha typeRelated to DUG3-probable glutamine amidotransferaseHeat stress transcription factor A-6bProteasome subunit alpha typeProteasome subunit alpha typeGlutamine--fructose-6-phosphate aminotransferase [isomerizing]Proteasome subunit alpha typeGlutamine-fructose-6-phosphate transaminase (Isomerizing)NAD(P)H-dependent glutamate synthase, putativeProteasome subunit beta 12Proteasome subunit betaProteasome subunit betaProteasome subunit alpha typeProteasome subunit betaAsparagine synthase (Glutamine-hydrolyzing)AmidophosphoribosyltransferaseProteasome subunit beta 2Glutamate synthase, large subunitProteasome subunit betaClass II glutamine amidotransferaseProteasome subunit betaProteasome subunit beta type-1Asparagine synthase BProteasome subunit betaProteasome subunit betaProteasome subunit betaClass II glutamine amidotransferaseProteasome subunit betaAsparagine synthase (Glutamine-hydrolyzing)Ferredoxin-dependent glutamate synthase, chloroplasticProteasome subunit alpha typeProteasome subunit betaProteasome subunit betaProteasome subunit betaProteasome subunit alpha typeAsparagine synthetaseASparagiNe SynthetaseYML096W-like proteinAsparagine synthetaseProbable proteasome subunit beta type-5Proteasome subunit betaAsparagine synthetase BProteasome subunit beta type-6, putativeProteasome subunit betaProteasome subunit betaAsparagine synthase (Glutamine-hydrolysing)Asparagine synthetase, glutamine-hydrolyzingProbable asparagine synthaseProteasome endopeptidase complexProteasome endopeptidase complexProteasome endopeptidase complex20S proteasome alpha subunit 7Proteasome subunit beta type 7-B, putativeProteasome subunit betaProteasome subunit beta type-1, putativeProteasome subunit betaProteasome endopeptidase complexProteasome subunit alpha typeProteasome subunit alpha typeGlutamine amidotransferaseProteasome subunit betaProteasome subunit betaProteasome subunit beta type 9Proteasome subunit betaAsparagine synthaseSIS domain containing proteinGlutamine--fructose-6-phosphate aminotransferase [isomerizing]Acyl-homoserine lactone acylase QuiPProteasome subunit betaProteasome subunit alpha typeProteasome subunit alpha typeProteasome subunit betaProteasome endopeptidase complexAsparagine synthetase, putativeGlucosamine-fructose-6-phosphate aminotransferase, putativeGlucosamine/fructose-6-phosphate aminotransferase, isomerizingGlutamine-fructose-6-phosphate transaminase (Isomerizing) (GlmS-2)Proteasome subunit alpha typePutative glutamine--fructose-6-phosphate aminotransferase [isomerizing]Proteasome subunit betaProteasome endopeptidase complexProteasome endopeptidase complexAcyl-homoserine lactone acylase QuiPAsparagine synthetase (Eurofung)
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FunFam 83: Proteasome subunit beta

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC TermAnnotationsEvidence
Proteasome endopeptidase complex. [EC: 3.4.25.1]
Cleavage of peptide bonds with very broad specificity.
  • A 20-S protein composed of 28 subunits arranged in four rings of seven.
  • The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity.
  • In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities.
  • The molecule is barrel-shaped, and the active sites are on the inner surfaces.
  • Terminal apertures restrict access of substrates to the active sites.
  • Inhibited by mercurial reagents and some inhibitors of serine endopeptidases.
  • Belongs to peptidase family T1.
  • Formerly EC 3.4.22.21, EC 3.4.24.5 and EC 3.4.99.46.
1 Q8SR11
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