The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Toll/interleukin-1 receptor homology (TIR) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: X-linked interleukin-1 receptor accessory protein-...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
17 P59823 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) Q7YQL9 (/ISS) Q7YQL9 (/ISS)
(7 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P59823 (/IPI) Q9NZN1 (/IPI) Q9NZN1 (/IPI) Q9NZN1 (/IPI) Q9NZN1 (/IPI) Q9NZN1 (/IPI) Q9NZN1 (/IPI) Q9NZN1 (/IPI)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
7 Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS)
Interleukin-1 receptor activity GO:0004908
Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
1 Q9NP60 (/TAS)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 P59823 (/IPI)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 P59824 (/IDA)
Voltage-gated calcium channel activity GO:0005245
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 P59823 (/ISO)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of neuron projection development GO:0010975
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
17 P59823 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) Q7YQL9 (/ISS) Q7YQL9 (/ISS)
(7 more)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
17 P59824 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) Q7YQL9 (/ISS) Q7YQL9 (/ISS)
(7 more)
Negative regulation of exocytosis GO:0045920
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
10 P59823 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) Q7YQL9 (/ISS) Q7YQL9 (/ISS)
Negative regulation of exocytosis GO:0045920
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
8 P59824 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA)
Regulation of presynapse assembly GO:1905606
Any process that modulates the frequency, rate or extent of presynapse assembly.
8 Q9NP60 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA)
Regulation of presynapse assembly GO:1905606
Any process that modulates the frequency, rate or extent of presynapse assembly.
8 Q9NP60 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157
The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
7 Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
7 Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS)
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
7 Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
7 Q9NZN1 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS)
Presynaptic membrane assembly GO:0097105
The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
7 Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS)
Regulation of postsynapse organization GO:0099175
Any process that modulates the physical form of a postsynapse.
7 Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA)
Regulation of postsynapse organization GO:0099175
Any process that modulates the physical form of a postsynapse.
7 Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP)
Trans-synaptic signaling by trans-synaptic complex GO:0099545
Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex.
7 Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA)
Trans-synaptic signaling by trans-synaptic complex GO:0099545
Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex.
7 Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP)
Regulation of presynapse assembly GO:1905606
Any process that modulates the frequency, rate or extent of presynapse assembly.
3 P59823 (/ISO) Q9ERS6 (/ISO) Q9ERS6 (/ISO)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157
The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
1 P59823 (/IDA)
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
1 Q9NP60 (/TAS)
Regulation of neuron projection development GO:0010975
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P59824 (/IDA)
Regulation of neuron projection development GO:0010975
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P59823 (/ISO)
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
1 B6ZK77 (/IMP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 P59823 (/IDA)
Negative regulation of exocytosis GO:0045920
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
1 P59823 (/ISO)
Positive regulation of dendrite morphogenesis GO:0050775
Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
1 P59823 (/IMP)
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 B6ZK77 (/IMP)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 P59823 (/IDA)
Presynaptic membrane assembly GO:0097105
The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.
1 P59823 (/IMP)
Regulation of postsynapse organization GO:0099175
Any process that modulates the physical form of a postsynapse.
1 P59823 (/ISO)
Trans-synaptic signaling by trans-synaptic complex GO:0099545
Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex.
1 P59823 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 P59823 (/ISS) P59824 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) P60029 (/ISS) Q7YQL9 (/ISS)
(1 more)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
9 P59824 (/IDA) Q9NP60 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 Q9NP60 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS) Q9NZN1 (/TAS)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
8 P59823 (/NAS) Q9NZN1 (/NAS) Q9NZN1 (/NAS) Q9NZN1 (/NAS) Q9NZN1 (/NAS) Q9NZN1 (/NAS) Q9NZN1 (/NAS) Q9NZN1 (/NAS)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
8 Q9NP60 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP) Q9NZN1 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA) Q9NZN1 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
7 Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
7 Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS) Q9NZN1 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 B6ZK78 (/IDA) F1QE87 (/IDA) F1RCA7 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
3 P59823 (/ISO) Q9ERS6 (/ISO) Q9ERS6 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P59823 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P59823 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P59823 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 B6ZK77 (/IDA)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
1 B6ZK77 (/IDA)
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P59824 (/IDA)
Integral component of postsynaptic density membrane GO:0099061
The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P59823 (/ISO)
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