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CATH Superfamily 3.40.50.10140

Toll/interleukin-1 receptor homology (TIR) domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Toll/interleukin-1 receptor homology (TIR) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Toll-like receptor 2
566
3D
 1o77E00 - 96.4
2
Interleukin 1 receptor accessory protein
433 - - 98.7
3
Toll-like receptor 7
311 - - 92.7
4
X-linked interleukin-1 receptor accessory protein-like 1
240
3D
 1t3gB00 - 64.1
5
Myeloid differentiation primary response protein MyD88
154
3D
 4eo7A01 - 88.0
7
Disease resistance protein
TIR-NBS-LRR class
154
3D
 5tecB00 - 95.3
6
Toll-like receptor 4
140 - - 80.3
8
Toll-like receptor 3
95 - - 88.7
9
X-linked interleukin-1 receptor accessory protein-like 1
86 - - 93.2
10
phosphoinositide 3-kinase adapter protein 1
83
3D
 5forA00 - 89.6
11
single Ig IL-1-related receptor isoform X1
78 - - 57.9
12
Sterile alpha and TIR motif-containing protein
73 - - 53.8
13
Sterile alpha and TIR motif containing 1
65 - - 39.5
14
TIR domain-containing adapter molecule 2
59 - - 67.1
15
Toll/interleukin-1 receptor domain-containing adapter protein
53
3D
 4lqdA00 - 40.3
16
Disease resistance protein
TIR-NBS class
46 - - 72.0
17
B cell scaffold protein with ankyrin repeats 1
46 - - 93.7
18
p-loop containing nucleoside triphosphate hydrolase superfamily protein
45 - - 65.7
19
18w protein
43 - - 71.5
20
Blast:Protein toll
40 - - 80.3
21
Toll receptor 13
35 - - 89.1
22
Myd88
23 - - 85.1
23
Sterile alpha and TIR motif-containing protein tir-1
19 - - 37.5
25
Disease resistance protein
TIR-NBS-LRR class
18
3D
 4c6tC00 - 87.9
24
TIR domain-containing adapter molecule 1
18
3D
 2m1xA00 - 64.2
26
Toll-like receptor 2
15 - - 92.4
27
Toll-6
14 - - 14.4
28
Protein kinase family protein
10 - - 0.8
29
TOLl
Drosophila
9 - - 3.5
30
Toll-like receptor 5b
8 - - 76.0
31
putative ST2L protein isoform X4
8 - - 12.1
36
Uncharacterized protein
6
3D
 4lzpC00 - 0.7
32
AGAP001590-PB
6 - - 12.8
33
Toll-4
6 - - 23.6
34
Tehao
5 - - 59.0
35
Sterile alpha and TIR motif containing 1
5 - - 22.1
40
Uncharacterized protein
4 - - 59.1
39
Putative serine/threonine-protein kinase pats1
4 - - 44.9
37
Disease resistance protein
TIR-NBS-LRR class
4 - - 0.0
38
interleukin-18 receptor 1 isoform X3
4 - - 12.9
43
Disease resistance protein CHS1
3 - - 6.2
41
Toll-like receptor 1
3 - - 70.6
42
Phosphoinositide-3-kinase adaptor protein 1
3 - - 0.0
44
Toll-like receptor adaptor molecule 1
3 - - 3.1
45
Uncharacterized protein
2 - - 0.0
55
Uncharacterized protein
2 - - 3.8
63
Interleukin 1 receptor accessory protein
2 - - 40.3
48
Uncharacterized protein
2 - - 9.7
61
Transmembrane receptors / ATP binding protein
2 - - 0.7
58
Putative serine/threonine-protein kinase pats1
2 - - 0.0
53
Uncharacterized protein
2 - - 5.5
49
Interleukin-1 receptor type I
2 - - 3.3
59
Disease resistance protein
TIR-NBS class
2 - - 0.0
47
Uncharacterized protein
2 - - 11.3
57
Disease resistance protein
TIR-NBS-LRR class
2 - - 0.0
51
Uncharacterized protein
2 - - 34.6
50
Uncharacterized protein
2 - - 26.7
52
Predicted protein
2 - - 44.2
64
Uncharacterized protein PHLOEM PROTEIN 2-LIKE A7
2 - - 41.5
54
Toll-like receptor2
2 - - 0.8
56
Uncharacterized protein
2 - - 0.0
62
Predicted protein
2 - - 0.0
46
Putative phosphoinositide 3-kinase adapter protein 1
2 - - 1.5
60
Toll-Interleukin receptor
2 - - 0.0
69
Uncharacterized protein
1 - - 0.0
74
Myeloid differentiation factor 88
1 - - 0.0
76
TIR-domain containing adaptor inducing INF-beta
1 - - 0.0
95
Uncharacterized protein
1 - - 0.0
67
Uncharacterized protein
1 - - 0.0
82
Uncharacterized protein
1 - - 0.0
80
Uncharacterized protein
1 - - 0.0
72
Uncharacterized protein
1 - - 0.0
91
Uncharacterized protein
1 - - 0.0
65
Uncharacterized protein
1 - - 0.0
70
Toll-like receptor 19
1 - - 0.0
68
Toll-like receptor 9
1 - - 0.0
93
Uncharacterized protein
1 - - 0.0
86
Protein tirA
1 - - 0.0
84
Protein CBG03616
1 - - 0.0
79
Uncharacterized protein
1 - - 0.0
88
Uncharacterized protein
1 - - 0.0
66
Uncharacterized protein
1 - - 0.0
73
Uncharacterized protein
1 - - 0.0
92
Uncharacterized protein
1 - - 0.0
71
Uncharacterized protein
1 - - 0.0
77
Uncharacterized protein
1 - - 0.0
85
Uncharacterized protein
1 - - 0.0
90
Uncharacterized protein
1 - - 0.0
81
Uncharacterized protein
1 - - 0.0
87
Uncharacterized protein
1 - - 0.0
75
Uncharacterized protein
1 - - 0.0
89
Predicted protein
1 - - 0.0
78
Interleukin 1 receptor accessory protein-like 2
1 - - 0.0
96
Uncharacterized protein
1 - - 0.0
94
Uncharacterized protein
1 - - 0.0
83
Uncharacterized protein
1 - - 0.0
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