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CATH Superfamily 3.40.140.10

Cytidine Deaminase, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cytidine Deaminase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 49: C->U-editing enzyme APOBEC-1 isoform X2

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
MRNA(cytosine(6666)) deaminase. [EC: 3.5.4.36]
Cytosine(6666) in apolipoprotein B mRNA + H(2)O = uracil(6666) in apolipoprotein B mRNA + NH(3).
  • The apolipoprotein B mRNA editing enzyme complex catalyzes the editing of apolipoprotein B mRNA at cytidine(6666) to uridine, thereby transforming the codon for glutamine-2153 to a termination codon.
  • Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport.
  • The catalytic component (APOBEC-1) contains zinc at the active site.
 13 A0A1U7Q2F3 A0A1U7Q2F3 P38483 P41238 P47855 P51908 P51908 Q3U9G8 Q3U9G8 Q694B3
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