The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"SH2 domain
".
FunFam 92: SH2 domain containing 1B
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | O14796 (/IPI) O35324 (/IPI) O35324 (/IPI) Q45HK4 (/IPI) |
|
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
|
2 | O35324 (/IDA) O35324 (/IDA) |
|
Signaling adaptor activity GO:0035591
The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.
|
2 | O35324 (/NAS) O35324 (/NAS) |
|
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
|
1 | O14796 (/TAS) |
There are 16 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
|
3 | O35324 (/IDA) O35324 (/IDA) Q45HK4 (/IDA) |
|
Negative regulation of natural killer cell mediated cytotoxicity GO:0045953
Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.
|
3 | O35324 (/IMP) O35324 (/IMP) Q45HK4 (/IMP) |
|
Positive regulation of natural killer cell mediated cytotoxicity GO:0045954
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
|
3 | O35324 (/IGI) O35324 (/IGI) Q45HK4 (/IGI) |
|
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
3 | O35324 (/IDA) O35324 (/IDA) Q45HK4 (/IDA) |
|
Leukocyte activation involved in immune response GO:0002366
A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
|
2 | O35324 (/IDA) O35324 (/IDA) |
|
Positive regulation of natural killer cell mediated immunity GO:0002717
Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.
|
2 | O35324 (/IMP) O35324 (/IMP) |
|
Natural killer cell inhibitory signaling pathway GO:0002769
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response.
|
2 | O35324 (/IMP) O35324 (/IMP) |
|
Positive regulation of signal transduction GO:0009967
Any process that activates or increases the frequency, rate or extent of signal transduction.
|
2 | O35324 (/NAS) O35324 (/NAS) |
|
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
2 | O35324 (/IMP) O35324 (/IMP) |
|
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
|
2 | O35324 (/IDA) O35324 (/IDA) |
|
Negative regulation of peptidyl-tyrosine phosphorylation GO:0050732
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
|
2 | O35324 (/IMP) O35324 (/IMP) |
|
Leukocyte activation involved in immune response GO:0002366
A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
|
1 | O14796 (/ISS) |
|
Positive regulation of natural killer cell mediated immunity GO:0002717
Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.
|
1 | O14796 (/ISS) |
|
Regulation of natural killer cell activation GO:0032814
Any process that modulates the frequency, rate or extent of natural killer cell activation.
|
1 | Q45HK4 (/IGI) |
|
Positive regulation of innate immune response GO:0045089
Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
|
1 | O14796 (/ISS) |
|
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
1 | O14796 (/TAS) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O14796 (/TAS) |
