CATH Superfamily 3.30.505.10

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
1	Tyrosine-protein kinase	983	3D	4k11A02	-	88.3
3	Signal transducer and activator of transcription	766	3D	4e68A04	-	96.0
2	Tensin 1	762	3D	2l6kA01	-	78.8
4	Tyrosine-protein kinase	759	3D	1opkA02	-	83.0
6	Phosphatidylinositol 3-kinase regulatory subunit alpha	679	3D	5aulA00	-	88.0
5	SHC-transforming protein 1 isoform 3	676	3D	1tceA00	-	83.9
7	E3 ubiquitin-protein ligase CBL	646	3D	3vrrA03	-	82.3
8	SH2B adapter protein 1 isoform 2	530	3D	2hdxF00	-	84.8
9	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma	522	3D	4fbnA02	-	90.8
12	Tyrosine-protein phosphatase non-receptor type	511	3D	6mddB02	-	86.3
10	Tyrosine-protein kinase	506	3D	4tziB00	-	92.1
11	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma	451	3D	4fbnA01	-	97.4
13	SH2 domain-containing protein 3C isoform X1	442		-	-	95.3
14	Phosphatidylinositol 3-kinase regulatory subunit alpha	425	3D	5gjiA00	-	75.4
18	Tyrosine-protein phosphatase non-receptor type	422	3D	1aydA00	-	81.4
15	Growth factor receptor-bound protein 10 isoform X1	415	3D	3m7fA00	-	87.5
22	Growth factor receptor-bound protein 2	381	3D	5cdwd00	-	77.8
16	B-cell linker protein isoform 2	374	3D	2eo6A01	-	99.5
17	Phosphatidylinositol 3-kinase regulatory subunit gamma b	354		-	-	74.7
19	Chimaerin	342	3D	3cxlA01	-	95.6
20	Tyrosine-protein kinase	337	3D	2kk6A00	-	82.9
21	Putative SH2 domain-containing adapter protein F	327		-	-	77.6
23	Tyrosine-protein kinase	305	3D	3eazA00	-	89.7
24	Vav guanine nucleotide exchange factor 2	296	3D	2rorA00	-	83.6
25	Signal transducer and activator of transcription	279		-	-	74.4
26	adapter molecule crk isoform X1	265	3D	2eyzA01	-	75.0
27	Cytoplasmic protein nck1	260	3D	2ci9B00	-	69.5
28	Suppressor of cytokine signaling 5	237	3D	2izvA00	-	78.5
29	Suppressor of cytokine signaling 7	235		-	-	83.6
31	Tyrosine-protein kinase	228	3D	4fl3A01	-	88.6
30	Transcription elongation factor spt6	218		-	-	90.5
32	Transcription elongation factor spt6	207		-	-	60.0
33	RAS p21 protein activator 1	192		-	-	53.5
34	SH2 domain-containing protein 4A	183		-	-	79.4
35	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	180	3D	2mk2A00	-	74.4
36	Suppressor of cytokine signaling 6	179	3D	2vifA01	-	80.8
37	Tyrosine-protein kinase	169		-	-	78.5
38	Tyrosine-protein kinase	157	3D	4fl3A03	-	69.8
39	src-like-adapter isoform X1	145		-	-	73.8
40	Tyrosine-protein kinase	140	3D	2ge9A00	-	70.8
41	Tyrosine-protein kinase	135		-	-	70.0
42	Cytokine-inducible SH2-containing protein b	134		-	-	78.6
43	SH3 domain binding protein 2	131	3D	2cr4A01	-	94.7
44	Tyrosine-protein kinase	131	3D	2dlyA00	-	91.9
45	Tyrosine-protein kinase	130	3D	2dm0A01	-	89.8
46	RAS p21 protein activator 1	118		-	-	44.6
49	Suppressor of cytokine signaling 2	114	3D	5bo4P01	-	73.0
47	Transcription elongation factor spt6	114		-	-	78.0
48	Signal transducer and transcription activator 6	112		-	-	81.2
50	Transcription elongation factor spt6	105		-	-	95.3
51	Tyrosine-protein kinase	104		-	-	98.1
52	Ras and Rab interactor 2	102		-	-	71.0
53	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide	101		-	-	72.7
54	Suppressor of cytokine signaling 1	96		-	-	79.4
56	Transcription elongation factor Spt6	94		-	-	92.0
55	Tyrosine-protein kinase	94		-	-	70.7
57	Signal transducer and activator of transcription	93		-	-	89.3
61	Tyrosine-protein kinase	93	3D	2k7aB00	-	73.5
58	SH2 domain-containing adapter protein D	92		-	-	85.6
59	hematopoietic SH2 domain-containing protein	92	3D	2cs0A01	-	91.8
60	Tyrosine-protein kinase	91	3D	2ekxA01	-	73.9
62	SH2 domain-containing protein 1A	91	3D	1m27A00	-	28.9
65	Transcription elongation factor SPT6	85	3D	5vkoA02	-	92.5
63	Tyrosine-protein kinase	82	3D	4xz1A03	-	54.9
66	suppressor of cytokine signaling 3	77	3D	4gl9H00	-	79.3
64	src-like-adapter 2 isoform X2	75	3D	4m4zA02	-	71.4
67	Src homology 2 domain-containing E	63		-	-	79.1
69	Signal transducer and activator of transcription	58	3D	1y1uC04	-	31.3
68	ras and Rab interactor 1	56		-	-	52.0
70	GRB2-related adapter protein 2	55	3D	5gjhC00	-	29.1
77	Tyrosine-protein kinase Lck	52	3D	5mtnA00	-	57.2
71	SH2 domain containing 3A	50		-	-	58.9
72	SH2 domain-containing protein 5	44		-	-	46.1
73	Tyrosine-protein kinase	40		-	-	95.2
74	Tyrosine-protein kinase	36	3D	1rjaA00	-	92.2
75	SH2 domain containing 2A	32		-	-	48.0
76	Signal transducing adaptor family member 2	32	3D	2el8A01	-	38.6
78	Tyrosine-protein kinase	29		-	-	76.1
79	Suppressor of cytokine signaling 7	28		-	-	38.7
80	Pi3K21B, isoform C	26		-	-	94.8
81	Transcription elongation factor spt6	24		-	-	94.2
82	Uncharacterized protein, isoform B	24		-	-	51.8
84	Signal transducing adaptor family member 1	24	3D	3mazA00	-	35.1
83	Ras GTPase-activating protein 1	23		-	-	17.9
85	Transcription elongation factor SPT6	23		-	-	23.9
86	SH2 domain protein B	22		-	-	67.3
88	Tyrosine-protein kinase	21		-	-	50.4
92	SH2 domain containing 1B	21	3D	1i3zA00	-	37.0
87	protein sprint isoform X1	21		-	-	9.8
90	Uncharacterized protein	19		-	-	4.1
105	Transcription elongation factor SPT6	19	3D	5vkoA01	-	34.6
91	Uncharacterized protein, isoform C	19		-	-	16.0
89	Transcription elongation factor spt6	19		-	-	90.7
93	Tyrosine-protein kinase	17		-	-	20.3
94	Cytokine-inducible SH2-containing protein	15		-	-	90.2
99	Signal transducer and activator of transcription	14	3D	1uusA04	-	78.0
96	SH2 domain-containing protein 4B-like	14		-	-	71.0
95	Signal transducer and activator of transcription	14		-	-	82.8
154	E3 ubiquitin-protein ligase CBL	14	3D	5hl0A03	-	20.9
97	Tyrosine-protein kinase	13		-	-	74.9
110	Cell death abnormality protein 2	13	3D	3qwyB01	-	51.6
101	Tyrosine-protein kinase	12		-	-	83.4
102	Tyrosine-protein kinase	12		-	-	56.5
103	Si:ch73-109i22.2	12		-	-	75.9
104	Phosphoinositide 3-kinase adapter subunit	12		-	-	96.1
100	phosphatidylinositol 3-kinase regulatory subunit gamma	12		-	-	71.7
98	Phosphoinositide phospholipase C	12		-	-	35.2
107	Transcription elongation factor SPT6	11		-	-	1.2
106	Tyrosine-protein kinase	11		-	-	79.9
108	Tyrosine-protein kinase	10		-	-	79.8
109	CRE-STA-2 protein	10		-	-	43.0
111	Suppressor of cytokine signaling, invertebrate	10		-	-	18.4
112	Si:ch211-25d12.7	10		-	-	49.7
120	Tyrosine-protein kinase Fyn	8	3D	1aouF00	-	37.3
114	Tyrosine-protein kinase	8		-	-	19.5
116	SH2 domain-containing protein 4B	8		-	-	74.1
113	Holliday-junction_resolvase-like_of_SPT6 /SH2_domain_containing_protein_-_putative	8		-	-	41.0
115	Tyrosine-protein kinase	8		-	-	70.9
118	SH2 domain-containing adapter protein B	7		-	-	29.1
119	Tyrosine-protein kinase	7		-	-	72.9
117	Non-specific protein-tyrosine kinase	7		-	-	79.6
126	Signal transducer and activator of transcription	6		-	-	50.2
124	tensin	6		-	-	9.8
122	Tyrosine-protein kinase	6		-	-	61.5
121	FYN isoform 7	6		-	-	14.1
125	GD21505	6		-	-	13.6
123	Tyrosine-protein kinase	6		-	-	9.0
129	Predicted protein	5		-	-	86.2
128	Tyrosine-protein kinase	5		-	-	63.1
130	Spermatocyte protein spe-8	5		-	-	19.0
136	Predicted protein	5		-	-	92.2
134	SH2-protein kinase domain containing protein	5		-	-	9.4
132	Tyrosine-protein kinase	5		-	-	16.7
131	Tyrosine-protein kinase	5		-	-	9.4
127	Signal transducer and activator of transcription 1	5		-	-	36.1
135	SHC-transforming protein homolog 1	5		-	-	70.9
133	Tyrosine-protein kinase	5		-	-	7.2
141	RIN Ras/Rab INteractor	4		-	-	9.1
139	Tyrosine-protein kinase	4		-	-	65.8
138	Dual specificity protein kinase shkE	4		-	-	69.7
142		4		-	-	8.8
143	Uncharacterized protein	4		-	-	8.0
145	Tyrosine-protein kinase	4		-	-	6.0
137	Phosphoinositide 3-kinase adapter subunit	4		-	-	48.5
140		4		-	-	78.7
144	SH2 domain protein 2A	4		-	-	18.3
146		4		-	-	88.2
147		3		-	-	30.6
153		3		-	-	11.5
155		3		-	-	0.0
157		3		-	-	1.2
151		3		-	-	0.0
152		3		-	-	3.1
162		3		-	-	9.7
161	Tyrosine-protein phosphatase non-receptor type	3		-	-	11.9
148		3		-	-	73.9
149		3		-	-	48.7
160		3		-	-	73.5
156		3		-	-	3.1
150		3		-	-	43.8
158		3		-	-	1.8
159		3		-	-	6.6
175		2		-	-	2.0
173		2		-	-	46.0
191		2		-	-	51.5
201		2		-	-	0.0
202		2		-	-	0.0
192		2		-	-	41.8
184		2		-	-	1.5
197		2		-	-	0.0
186		2		-	-	9.2
165		2		-	-	17.6
163		2		-	-	12.5
180		2		-	-	0.0
172		2		-	-	44.9
171		2		-	-	44.6
167		2		-	-	29.2
203		2		-	-	1.3
193		2		-	-	0.0
195		2		-	-	8.0
188		2		-	-	0.0
189		2		-	-	35.1
177		2		-	-	0.0
176		2		-	-	0.0
174		2		-	-	4.7
198		2		-	-	0.0
170		2		-	-	47.9
199		2		-	-	33.8
183		2		-	-	0.0
185		2		-	-	1.6
166		2		-	-	22.6
164		2		-	-	16.5
179		2		-	-	0.0
200		2		-	-	44.9
178		2		-	-	3.3
190		2		-	-	43.8
187		2		-	-	4.9
194		2		-	-	1.2
204		2		-	-	7.6
196		2		-	-	3.3
181		2		-	-	3.9
182		2		-	-	0.0
169		2		-	-	43.2
168		2		-	-	42.8
239		1		-	-	0.0
241		1		-	-	0.0
242		1		-	-	0.0
238		1		-	-	0.0
229		1		-	-	0.0
228		1		-	-	0.0
265		1		-	-	0.0
207		1		-	-	0.0
218		1		-	-	0.0
219		1		-	-	0.0
263		1		-	-	0.0
253		1		-	-	0.0
247		1		-	-	0.0
255		1		-	-	0.0
243		1		-	-	0.0
236		1		-	-	0.0
220		1		-	-	0.0
257		1		-	-	0.0
245		1		-	-	0.0
234		1		-	-	0.0
230		1		-	-	0.0
272		1		-	-	0.0
226		1		-	-	0.0
224		1		-	-	0.0
205		1		-	-	0.0
271		1		-	-	0.0
267		1		-	-	0.0
262		1		-	-	0.0
214		1		-	-	0.0
216		1		-	-	0.0
261		1		-	-	0.0
251		1		-	-	0.0
252		1		-	-	0.0
210		1		-	-	0.0
270		1		-	-	0.0
232		1		-	-	0.0
248		1		-	-	0.0
249		1		-	-	0.0
231		1		-	-	0.0
222		1		-	-	0.0
208		1		-	-	0.0
217		1		-	-	0.0
221		1		-	-	0.0
209		1		-	-	0.0
266		1		-	-	0.0
211		1		-	-	0.0
250		1		-	-	0.0
227		1		-	-	0.0
212		1		-	-	0.0
264		1		-	-	0.0
260		1		-	-	0.0
254		1		-	-	0.0
256		1		-	-	0.0
237		1		-	-	0.0
235		1		-	-	0.0
244		1		-	-	0.0
233		1		-	-	0.0
246		1		-	-	0.0
225		1		-	-	0.0
240		1		-	-	0.0
206		1		-	-	0.0
223		1		-	-	0.0
213		1		-	-	0.0
269		1		-	-	0.0
215		1		-	-	0.0
268		1		-	-	0.0
258		1		-	-	0.0
259		1		-	-	0.0

Network disruptions

Functional Families

Browse Functional Families