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1 keywords

CATH Domain 4gl9H00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.505 SHC Adaptor Protein
Homologous Superfamily 3.30.505.10 SH2 domain

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family suppressor of cytokine signaling 3

Enzyme Information

UniProtKB Entries (1)

Q62120
JAK2_MOUSE
Mus musculus
Tyrosine-protein kinase JAK2

PDB Structure

PDB 4GL9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
Kershaw, N.J., Murphy, J.M., Liau, N.P., Varghese, L.N., Laktyushin, A., Whitlock, E.L., Lucet, I.S., Nicola, N.A., Babon, J.J.
Nat.Struct.Mol.Biol.
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