The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Tensin 1Tyrosine-protein kinaseB-cell linker protein isoform 2Suppressor of cytokine signaling 6SH3 domain binding protein 2Tyrosine-protein kinaseSuppressor of cytokine signaling 2Tyrosine-protein kinaseSH2 domain-containing protein 1Asrc-like-adapter 2 isoform X2suppressor of cytokine signaling 3GRB2-related adapter protein 2Signal transducing adaptor family member 2Tyrosine-protein kinase LckSignal transducing adaptor family member 1Tyrosine-protein kinase FynSC:2SHC-transforming protein 1 isoform 3Phosphatidylinositol 3-kinase regulatory subunit alpha1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaTyrosine-protein phosphatase non-receptor typePhosphatidylinositol 3-kinase regulatory subunit alphaTyrosine-protein kinaseTyrosine-protein kinaseTyrosine-protein kinasehematopoietic SH2 domain-containing proteinTyrosine-protein kinaseTyrosine-protein kinaseTyrosine-protein kinaseCell death abnormality protein 2SC:3E3 ubiquitin-protein ligase CBLTyrosine-protein kinaseSignal transducer and activator of transcriptionSignal transducer and activator of transcriptionE3 ubiquitin-protein ligase CBLSC:4Suppressor of cytokine signaling 5SC:5Signal transducer and activator of transcriptionChimaerinTranscription elongation factor SPT6Transcription elongation factor SPT6SC:6Growth factor receptor-bound protein 2Tyrosine-protein kinaseTyrosine-protein kinaseSH2B adapter protein 1 isoform 21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaSH2 domain-containing protein 3C isoform X1Growth factor receptor-bound protein 10 isoform X1Phosphatidylinositol 3-kinase regulatory subunit gamma bTyrosine-protein phosphatase non-receptor typePutative SH2 domain-containing adapter protein FTyrosine-protein kinaseVav guanine nucleotide exchange factor 2Signal transducer and activator of transcriptionadapter molecule crk isoform X1Cytoplasmic protein nck1Suppressor of cytokine signaling 7Transcription elongation factor spt6Tyrosine-protein kinaseTranscription elongation factor spt6RAS p21 protein activator 1SH2 domain-containing protein 4Aphosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1Tyrosine-protein kinasesrc-like-adapter isoform X1Tyrosine-protein kinaseCytokine-inducible SH2-containing protein bRAS p21 protein activator 1Transcription elongation factor spt6Signal transducer and transcription activator 6Transcription elongation factor spt6Tyrosine-protein kinaseRas and Rab interactor 2Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositideSuppressor of cytokine signaling 1Tyrosine-protein kinaseTranscription elongation factor Spt6Signal transducer and activator of transcriptionSH2 domain-containing adapter protein DSrc homology 2 domain-containing Eras and Rab interactor 1SH2 domain containing 3ASH2 domain-containing protein 5Tyrosine-protein kinaseSH2 domain containing 2ATyrosine-protein kinaseSuppressor of cytokine signaling 7Pi3K21B, isoform CTranscription elongation factor spt6Uncharacterized protein, isoform BRas GTPase-activating protein 1Transcription elongation factor SPT6SH2 domain protein Bprotein sprint isoform X1Tyrosine-protein kinaseTranscription elongation factor spt6Uncharacterized proteinUncharacterized protein, isoform CSH2 domain containing 1BTyrosine-protein kinaseCytokine-inducible SH2-containing proteinSignal transducer and activator of transcriptionSH2 domain-containing protein 4B-likeTyrosine-protein kinasePhosphoinositide phospholipase Cphosphatidylinositol 3-kinase regulatory subunit gammaTyrosine-protein kinaseTyrosine-protein kinaseSi:ch73-109i22.2Phosphoinositide 3-kinase adapter subunitTyrosine-protein kinaseTranscription elongation factor SPT6Tyrosine-protein kinaseCRE-STA-2 proteinSuppressor of cytokine signaling, invertebrateSi:ch211-25d12.7Holliday-junction_resolvase-like_of_SPT6 /SH2_domain_containing_protein_-_putativeTyrosine-protein kinaseTyrosine-protein kinaseSH2 domain-containing protein 4BNon-specific protein-tyrosine kinaseSH2 domain-containing adapter protein BTyrosine-protein kinaseFYN isoform 7Tyrosine-protein kinaseTyrosine-protein kinasetensinGD21505Signal transducer and activator of transcriptionSignal transducer and activator of transcription 1Tyrosine-protein kinasePredicted proteinSpermatocyte protein spe-8Tyrosine-protein kinaseTyrosine-protein kinaseTyrosine-protein kinaseSH2-protein kinase domain containing proteinSHC-transforming protein homolog 1Predicted proteinPhosphoinositide 3-kinase adapter subunitDual specificity protein kinase shkETyrosine-protein kinaseRIN (Ras/Rab INteractor) homologUncharacterized proteinSH2 domain protein 2ATyrosine-protein kinaseTyrosine-protein phosphatase non-receptor type
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FunFam 44: Tyrosine-protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
5 Q9V9J3 (/NAS) Q9V9J3 (/NAS) Q9V9J3 (/NAS) Q9V9J3 (/NAS) Q9V9J3 (/NAS)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
5 Q9V9J3 (/IDA) Q9V9J3 (/IDA) Q9V9J3 (/IDA) Q9V9J3 (/IDA) Q9V9J3 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P42685 (/EXP)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 Q62662 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 Q922K9 (/ISO)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
1 P42685 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P42685 (/IPI)
Showing 1 to 7 of 7 entries

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 Q9V9J3 (/IDA) Q9V9J3 (/IDA) Q9V9J3 (/IDA) Q9V9J3 (/IDA) Q9V9J3 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
5 Q9V9J3 (/IGI) Q9V9J3 (/IGI) Q9V9J3 (/IGI) Q9V9J3 (/IGI) Q9V9J3 (/IGI)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
5 Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP)
Dorsal closure, spreading of leading edge cells GO:0007395
Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa.
5 Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
5 Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
5 Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
5 Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
5 Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP) Q9V9J3 (/IMP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
5 Q9V9J3 (/TAS) Q9V9J3 (/TAS) Q9V9J3 (/TAS) Q9V9J3 (/TAS) Q9V9J3 (/TAS)
Showing 1 to 10 of 33 entries

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P42685 (/TAS) Q9V9J3 (/TAS) Q9V9J3 (/TAS) Q9V9J3 (/TAS) Q9V9J3 (/TAS) Q9V9J3 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q9V9J3 (/HDA) Q9V9J3 (/HDA) Q9V9J3 (/HDA) Q9V9J3 (/HDA) Q9V9J3 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 Q9V9J3 (/HDA) Q9V9J3 (/HDA) Q9V9J3 (/HDA) Q9V9J3 (/HDA) Q9V9J3 (/HDA)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
5 Q9V9J3 (/IDA) Q9V9J3 (/IDA) Q9V9J3 (/IDA) Q9V9J3 (/IDA) Q9V9J3 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P42685 (/TAS)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 P42685 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P42685 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q922K9 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P42685 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P42685 (/IDA)
Showing 1 to 10 of 16 entries
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