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CATH Superfamily 3.30.505.10

SH2 domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1Tensin 1Tyrosine-protein kinaseB-cell linker protein isoform 2Suppressor of cytokine signaling 6SH3 domain binding protein 2Tyrosine-protein kinaseSuppressor of cytokine signaling 2Tyrosine-protein kinaseSH2 domain-containing protein 1Asrc-like-adapter 2 isoform X2suppressor of cytokine signaling 3GRB2-related adapter protein 2Signal transducing adaptor family member 2Tyrosine-protein kinase LckSignal transducing adaptor family member 1Tyrosine-protein kinase FynSC:2SHC-transforming protein 1 isoform 3Phosphatidylinositol 3-kinase regulatory subunit alpha1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaTyrosine-protein phosphatase non-receptor typePhosphatidylinositol 3-kinase regulatory subunit alphaTyrosine-protein kinaseTyrosine-protein kinaseTyrosine-protein kinasehematopoietic SH2 domain-containing proteinTyrosine-protein kinaseTyrosine-protein kinaseTyrosine-protein kinaseCell death abnormality protein 2SC:3E3 ubiquitin-protein ligase CBLTyrosine-protein kinaseSignal transducer and activator of transcriptionSignal transducer and activator of transcriptionE3 ubiquitin-protein ligase CBLSC:4Suppressor of cytokine signaling 5SC:5Signal transducer and activator of transcriptionChimaerinTranscription elongation factor SPT6Transcription elongation factor SPT6SC:6Growth factor receptor-bound protein 2Tyrosine-protein kinaseTyrosine-protein kinaseSH2B adapter protein 1 isoform 21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gammaSH2 domain-containing protein 3C isoform X1Growth factor receptor-bound protein 10 isoform X1Phosphatidylinositol 3-kinase regulatory subunit gamma bTyrosine-protein phosphatase non-receptor typePutative SH2 domain-containing adapter protein FTyrosine-protein kinaseVav guanine nucleotide exchange factor 2Signal transducer and activator of transcriptionadapter molecule crk isoform X1Cytoplasmic protein nck1Suppressor of cytokine signaling 7Transcription elongation factor spt6Tyrosine-protein kinaseTranscription elongation factor spt6RAS p21 protein activator 1SH2 domain-containing protein 4Aphosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1Tyrosine-protein kinasesrc-like-adapter isoform X1Tyrosine-protein kinaseCytokine-inducible SH2-containing protein bRAS p21 protein activator 1Transcription elongation factor spt6Signal transducer and transcription activator 6Transcription elongation factor spt6Tyrosine-protein kinaseRas and Rab interactor 2Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositideSuppressor of cytokine signaling 1Tyrosine-protein kinaseTranscription elongation factor Spt6Signal transducer and activator of transcriptionSH2 domain-containing adapter protein DSrc homology 2 domain-containing Eras and Rab interactor 1SH2 domain containing 3ASH2 domain-containing protein 5Tyrosine-protein kinaseSH2 domain containing 2ATyrosine-protein kinaseSuppressor of cytokine signaling 7Pi3K21B, isoform CTranscription elongation factor spt6Uncharacterized protein, isoform BRas GTPase-activating protein 1Transcription elongation factor SPT6SH2 domain protein Bprotein sprint isoform X1Tyrosine-protein kinaseTranscription elongation factor spt6Uncharacterized proteinUncharacterized protein, isoform CSH2 domain containing 1BTyrosine-protein kinaseCytokine-inducible SH2-containing proteinSignal transducer and activator of transcriptionSH2 domain-containing protein 4B-likeTyrosine-protein kinasePhosphoinositide phospholipase Cphosphatidylinositol 3-kinase regulatory subunit gammaTyrosine-protein kinaseTyrosine-protein kinaseSi:ch73-109i22.2Phosphoinositide 3-kinase adapter subunitTyrosine-protein kinaseTranscription elongation factor SPT6Tyrosine-protein kinaseCRE-STA-2 proteinSuppressor of cytokine signaling, invertebrateSi:ch211-25d12.7Holliday-junction_resolvase-like_of_SPT6 /SH2_domain_containing_protein_-_putativeTyrosine-protein kinaseTyrosine-protein kinaseSH2 domain-containing protein 4BNon-specific protein-tyrosine kinaseSH2 domain-containing adapter protein BTyrosine-protein kinaseFYN isoform 7Tyrosine-protein kinaseTyrosine-protein kinasetensinGD21505Signal transducer and activator of transcriptionSignal transducer and activator of transcription 1Tyrosine-protein kinasePredicted proteinSpermatocyte protein spe-8Tyrosine-protein kinaseTyrosine-protein kinaseTyrosine-protein kinaseSH2-protein kinase domain containing proteinSHC-transforming protein homolog 1Predicted proteinPhosphoinositide 3-kinase adapter subunitDual specificity protein kinase shkETyrosine-protein kinaseRIN (Ras/Rab INteractor) homologUncharacterized proteinSH2 domain protein 2ATyrosine-protein kinaseTyrosine-protein phosphatase non-receptor type
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FunFam 132: Tyrosine-protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
 1 G5ECJ6 (/IMP)
Showing 1 to 1 of 1 entries

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
 1 G5ECJ6 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
 1 G5ECJ6 (/IMP)
Larval feeding behavior GO:0030536
Feeding behavior in a larval (immature) organism.
 1 G5ECJ6 (/IMP)
Pharyngeal pumping GO:0043050
The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes.
 1 G5ECJ6 (/IMP)
Muscle fiber development GO:0048747
The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
 1 G5ECJ6 (/IMP)
Showing 1 to 5 of 5 entries

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 1 G5ECJ6 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
 1 G5ECJ6 (/IDA)
Showing 1 to 2 of 2 entries
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