The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 25: Platelet-derived growth factor receptor alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 62 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
13 O97799 (/ISS) P05532 (/ISS) P07333 (/ISS) P13369 (/ISS) P43481 (/ISS) P43481 (/ISS) Q00495 (/ISS) Q28317 (/ISS) Q28889 (/ISS) Q28889 (/ISS)
(3 more)
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
10 O97799 (/ISS) P05532 (/ISS) P43481 (/ISS) P43481 (/ISS) Q28317 (/ISS) Q28889 (/ISS) Q28889 (/ISS) Q2HWD6 (/ISS) Q76II0 (/ISS) Q76II0 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 P05532 (/IPI) P05622 (/IPI) P07333 (/IPI) P09581 (/IPI) P09581 (/IPI) P09619 (/IPI) P10721 (/IPI) P10721 (/IPI) P16234 (/IPI) Q05030 (/IPI)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
5 A0A0G2JTL4 (/IDA) A0A0G2JTL4 (/IDA) P09619 (/IDA) Q05030 (/IDA) Q63116 (/IDA)
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
5 P09581 (/IDA) P09581 (/IDA) P10721 (/IDA) P10721 (/IDA) P16234 (/IDA)
Cytokine binding GO:0019955
Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
5 P07333 (/IDA) P09581 (/IDA) P09581 (/IDA) P10721 (/IDA) P10721 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
4 P07333 (/TAS) P10721 (/TAS) P10721 (/TAS) Q05030 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P09581 (/IPI) P09581 (/IPI) P10721 (/IPI) P10721 (/IPI)
Macrophage colony-stimulating factor receptor activity GO:0005011
Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
3 P07333 (/IMP) P09581 (/IMP) P09581 (/IMP)
Macrophage colony-stimulating factor receptor activity GO:0005011
Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
3 P07333 (/ISS) P13369 (/ISS) Q00495 (/ISS)
Showing 1 to 10 of 62 entries

There are 436 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
16 O97799 (/ISS) P05622 (/ISS) P13369 (/ISS) P20786 (/ISS) P26618 (/ISS) P43481 (/ISS) P43481 (/ISS) Q00495 (/ISS) Q05030 (/ISS) Q28317 (/ISS)
(6 more)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
13 O97799 (/ISS) P10721 (/ISS) P10721 (/ISS) P13369 (/ISS) P43481 (/ISS) P43481 (/ISS) Q00495 (/ISS) Q28317 (/ISS) Q28889 (/ISS) Q28889 (/ISS)
(3 more)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
13 A0A0G2JTL4 (/IDA) A0A0G2JTL4 (/IDA) P05532 (/IDA) P05622 (/IDA) P07333 (/IDA) P09581 (/IDA) P09581 (/IDA) P09619 (/IDA) P10721 (/IDA) P10721 (/IDA)
(3 more)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
13 O97799 (/ISS) P05532 (/ISS) P05622 (/ISS) P20786 (/ISS) P43481 (/ISS) P43481 (/ISS) Q05030 (/ISS) Q28317 (/ISS) Q28889 (/ISS) Q28889 (/ISS)
(3 more)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
12 A0A0G2JTL4 (/IDA) A0A0G2JTL4 (/IDA) P05622 (/IDA) P07333 (/IDA) P09581 (/IDA) P09581 (/IDA) P09619 (/IDA) P10721 (/IDA) P10721 (/IDA) P16234 (/IDA)
(2 more)
Ovarian follicle development GO:0001541
The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
11 O97799 (/ISS) P10721 (/ISS) P10721 (/ISS) P43481 (/ISS) P43481 (/ISS) Q28317 (/ISS) Q28889 (/ISS) Q28889 (/ISS) Q2HWD6 (/ISS) Q76II0 (/ISS)
(1 more)
Immature B cell differentiation GO:0002327
The process in which a precursor cell type acquires the specialized features of an immature B cell.
11 O97799 (/ISS) P10721 (/ISS) P10721 (/ISS) P43481 (/ISS) P43481 (/ISS) Q28317 (/ISS) Q28889 (/ISS) Q28889 (/ISS) Q2HWD6 (/ISS) Q76II0 (/ISS)
(1 more)
Dendritic cell cytokine production GO:0002371
Any process that contributes to cytokine production by a dendritic cell.
11 O97799 (/ISS) P10721 (/ISS) P10721 (/ISS) P43481 (/ISS) P43481 (/ISS) Q28317 (/ISS) Q28889 (/ISS) Q28889 (/ISS) Q2HWD6 (/ISS) Q76II0 (/ISS)
(1 more)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
11 O97799 (/ISS) P10721 (/ISS) P10721 (/ISS) P43481 (/ISS) P43481 (/ISS) Q28317 (/ISS) Q28889 (/ISS) Q28889 (/ISS) Q2HWD6 (/ISS) Q76II0 (/ISS)
(1 more)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
11 O97799 (/ISS) P10721 (/ISS) P10721 (/ISS) P43481 (/ISS) P43481 (/ISS) Q28317 (/ISS) Q28889 (/ISS) Q28889 (/ISS) Q2HWD6 (/ISS) Q76II0 (/ISS)
(1 more)
Showing 1 to 10 of 436 entries

There are 56 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 A0A024RDA0 (/IDA) A0A024RDA0 (/IDA) A0A0G2JW59 (/IDA) P07333 (/IDA) P09581 (/IDA) P09581 (/IDA) P10721 (/IDA) P10721 (/IDA) P16234 (/IDA) P20786 (/IDA)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 A0A0G2JTL4 (/IDA) A0A0G2JTL4 (/IDA) A0A0G2JW59 (/IDA) P05622 (/IDA) P20786 (/IDA) P26618 (/IDA) Q05030 (/IDA) Q63116 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P05532 (/TAS) P07333 (/TAS) P09619 (/TAS) P10721 (/TAS) P10721 (/TAS) P16234 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
6 P05532 (/IDA) P05622 (/IDA) P09581 (/IDA) P09581 (/IDA) P26618 (/IDA) Q05030 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 A0A0G2JW59 (/IDA) P16234 (/IDA) P20786 (/IDA) P26618 (/IDA) Q05030 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P05622 (/ISS) P09619 (/ISS) P16234 (/ISS) P26618 (/ISS) Q6QNF3 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P05622 (/ISS) P09619 (/ISS) P16234 (/ISS) P26618 (/ISS) Q6QNF3 (/ISS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
5 P16234 (/ISS) P20786 (/ISS) P26619 (/ISS) Q9DE49 (/ISS) Q9PUF6 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P05532 (/ISO) P05622 (/ISO) P09581 (/ISO) P09581 (/ISO) P26618 (/ISO)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
5 P16234 (/ISS) P20786 (/ISS) P26619 (/ISS) Q9DE49 (/ISS) Q9PUF6 (/ISS)
Showing 1 to 10 of 56 entries
CATH-Gene3D is a Global Biodata Core Resource Learn more...