The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 13: ATP-dependent RNA helicase DDX1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 22 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
Helicase activity GO:0004386
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
Nuclease activity GO:0004518
Catalysis of the hydrolysis of ester linkages within nucleic acids.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
Poly(A) binding GO:0008143
Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
DNA/RNA helicase activity GO:0033677
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | Q91VR5 (/IPI) Q92499 (/IPI) Q92499 (/IPI) Q92499 (/IPI) Q92499 (/IPI) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
4 | Q92499 (/IDA) Q92499 (/IDA) Q92499 (/IDA) Q92499 (/IDA) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
4 | Q92499 (/IDA) Q92499 (/IDA) Q92499 (/IDA) Q92499 (/IDA) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
4 | Q92499 (/HDA) Q92499 (/HDA) Q92499 (/HDA) Q92499 (/HDA) |
Showing 1 to 10 of 22 entries
There are 22 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
|
12 |
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q641Y8 (/ISS)
Q92499 (/ISS)
Q92499 (/ISS)
(2 more) |
|
Spliceosomal complex assembly GO:0000245
The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.
|
4 | Q92499 (/NAS) Q92499 (/NAS) Q92499 (/NAS) Q92499 (/NAS) |
|
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
4 | Q92499 (/IDA) Q92499 (/IDA) Q92499 (/IDA) Q92499 (/IDA) |
|
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
|
4 | Q92499 (/IMP) Q92499 (/IMP) Q92499 (/IMP) Q92499 (/IMP) |
|
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
|
4 | Q92499 (/TAS) Q92499 (/TAS) Q92499 (/TAS) Q92499 (/TAS) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
4 | Q92499 (/NAS) Q92499 (/NAS) Q92499 (/NAS) Q92499 (/NAS) |
|
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
4 | Q92499 (/IEP) Q92499 (/IEP) Q92499 (/IEP) Q92499 (/IEP) |
Showing 1 to 10 of 22 entries
There are 26 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
16 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(6 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
13 |
A0A087X2G1 (/IDA)
A3RJH1 (/IDA)
A3RJH1 (/IDA)
A3RJH1 (/IDA)
A3RJH1 (/IDA)
F1T0B3 (/IDA)
F1T0B3 (/IDA)
F1T0B3 (/IDA)
Q91VR5 (/IDA)
Q92499 (/IDA)
(3 more) |
|
TRNA-splicing ligase complex GO:0072669
A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.
|
13 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(3 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
12 |
A0A087X2G1 (/IDA)
A3RJH1 (/IDA)
A3RJH1 (/IDA)
A3RJH1 (/IDA)
A3RJH1 (/IDA)
F1T0B3 (/IDA)
F1T0B3 (/IDA)
F1T0B3 (/IDA)
Q92499 (/IDA)
Q92499 (/IDA)
(2 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
12 |
A2VD92 (/ISS)
A2VD92 (/ISS)
Q0IIK5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q4R7L5 (/ISS)
Q5NVJ8 (/ISS)
Q5XH91 (/ISS)
(2 more) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
9 | Q0IIK5 (/ISS) Q4R7L5 (/ISS) Q4R7L5 (/ISS) Q4R7L5 (/ISS) Q4R7L5 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q641Y8 (/ISS) Q91VR5 (/ISS) |
|
Cleavage body GO:0071920
A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing.
|
9 | Q0IIK5 (/ISS) Q4R7L5 (/ISS) Q4R7L5 (/ISS) Q4R7L5 (/ISS) Q4R7L5 (/ISS) Q4R7L5 (/ISS) Q5NVJ8 (/ISS) Q641Y8 (/ISS) Q91VR5 (/ISS) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
5 | Q91VR5 (/IDA) Q92499 (/IDA) Q92499 (/IDA) Q92499 (/IDA) Q92499 (/IDA) |
Showing 1 to 10 of 26 entries
