CATH Superfamily 2.20.70.10

FunFam 55: E3 ubiquitin-protein ligase NEDD4-like isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Protein binding GO:0005515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	7	A0A0G2JUY1 (/IPI) A0A0G2JXP3 (/IPI) F1LRN8 (/IPI) P46935 (/IPI) P46935 (/IPI) Q62940 (/IPI) Q8CFI0 (/IPI)
Ubiquitin-protein transferase activity GO:0004842 Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.	4	A0A0G2JUY1 (/IDA) A0A0G2JXP3 (/IDA) F1LRN8 (/IDA) Q62940 (/IDA)
Ubiquitin-protein transferase activity GO:0004842 Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.	3	P46935 (/ISO) P46935 (/ISO) Q8CFI0 (/ISO)
Sodium channel inhibitor activity GO:0019871 Stops, prevents, or reduces the activity of a sodium channel.	3	P46935 (/IDA) P46935 (/IDA) Q8CFI0 (/IDA)
Ubiquitin protein ligase activity GO:0061630 Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.	3	P46935 (/IDA) P46935 (/IDA) Q8CFI0 (/IDA)
Protein C-terminus binding GO:0008022 Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.	2	P46935 (/ISO) P46935 (/ISO)
Ionotropic glutamate receptor binding GO:0035255 Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.	2	P46935 (/IDA) P46935 (/IDA)
Phosphoserine residue binding GO:0050815 Interacting selectively and non-covalently with a phosphorylated serine residue within a protein.	2	P46935 (/IDA) P46935 (/IDA)
Phosphothreonine residue binding GO:0050816 Interacting selectively and non-covalently with a phosphorylated threonine residue within a protein.	2	P46935 (/IDA) P46935 (/IDA)
Proline-rich region binding GO:0070064 Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.	2	P46935 (/IPI) P46935 (/IPI)
Protein C-terminus binding GO:0008022 Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.	1	Q62940 (/IDA)
Protein C-terminus binding GO:0008022 Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.	1	Q62940 (/IPI)
Potassium channel regulator activity GO:0015459 Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).	1	Q8CFI0 (/ISO)
Sodium channel regulator activity GO:0017080 Modulates the activity of a sodium channel.	1	Q8CFI0 (/ISO)
Potassium channel inhibitor activity GO:0019870 Stops, prevents, or reduces the activity of a potassium channel.	1	F1LRN8 (/IMP)
Potassium channel inhibitor activity GO:0019870 Stops, prevents, or reduces the activity of a potassium channel.	1	Q8CFI0 (/ISO)
Sodium channel inhibitor activity GO:0019871 Stops, prevents, or reduces the activity of a sodium channel.	1	Q8CFI0 (/ISO)
Ion channel binding GO:0044325 Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.	1	H0VCR8 (/IPI)
Ion channel binding GO:0044325 Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.	1	Q8CFI0 (/ISO)

There are 67 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Protein monoubiquitination GO:0006513 Addition of a single ubiquitin group to a protein.	3	A0A0G2JUY1 (/IMP) A0A0G2JXP3 (/IMP) F1LRN8 (/IMP)
Negative regulation of sodium ion transport GO:0010766 Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	3	P46935 (/IDA) P46935 (/IDA) Q8CFI0 (/IDA)
Protein ubiquitination GO:0016567 The process in which one or more ubiquitin groups are added to a protein.	3	P46935 (/ISO) P46935 (/ISO) Q8CFI0 (/ISO)
Positive regulation of protein catabolic process GO:0045732 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.	3	A0A0G2JUY1 (/IMP) A0A0G2JXP3 (/IMP) F1LRN8 (/IMP)
Positive regulation of protein catabolic process GO:0045732 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.	3	P46935 (/ISO) P46935 (/ISO) Q8CFI0 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122 Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.	2	P46935 (/IMP) P46935 (/IMP)
Adaptive immune response GO:0002250 An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).	2	P46935 (/IMP) P46935 (/IMP)
Outflow tract morphogenesis GO:0003151 The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.	2	P46935 (/IGI) P46935 (/IGI)
Outflow tract morphogenesis GO:0003151 The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.	2	P46935 (/IMP) P46935 (/IMP)
Endocardial cushion development GO:0003197 The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.	2	P46935 (/IGI) P46935 (/IGI)
Endocardial cushion development GO:0003197 The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.	2	P46935 (/IMP) P46935 (/IMP)
Ubiquitin-dependent protein catabolic process GO:0006511 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.	2	P46935 (/IMP) P46935 (/IMP)
Protein monoubiquitination GO:0006513 Addition of a single ubiquitin group to a protein.	2	P46935 (/IDA) P46935 (/IDA)
Neuromuscular junction development GO:0007528 A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.	2	P46935 (/IMP) P46935 (/IMP)
Protein ubiquitination GO:0016567 The process in which one or more ubiquitin groups are added to a protein.	2	P46935 (/IDA) P46935 (/IDA)
Protein ubiquitination GO:0016567 The process in which one or more ubiquitin groups are added to a protein.	2	Q62940 (/ISS) Q8CFI0 (/ISS)
Negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.	2	P46935 (/IDA) P46935 (/IDA)
T cell activation GO:0042110 The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.	2	P46935 (/IMP) P46935 (/IMP)
Positive regulation of protein catabolic process GO:0045732 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.	2	P46935 (/IDA) P46935 (/IDA)
Blood vessel morphogenesis GO:0048514 The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.	2	P46935 (/IGI) P46935 (/IGI)
Blood vessel morphogenesis GO:0048514 The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.	2	P46935 (/IMP) P46935 (/IMP)
Regulation of dendrite morphogenesis GO:0048814 Any process that modulates the frequency, rate or extent of dendrite morphogenesis.	2	P46935 (/IMP) P46935 (/IMP)
Regulation of dendrite morphogenesis GO:0048814 Any process that modulates the frequency, rate or extent of dendrite morphogenesis.	2	P46935 (/ISO) P46935 (/ISO)
Regulation of synapse organization GO:0050807 Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).	2	P46935 (/IMP) P46935 (/IMP)
Protein K63-linked ubiquitination GO:0070534 A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.	2	P46935 (/ISO) P46935 (/ISO)
Protein K63-linked ubiquitination GO:0070534 A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.	2	P46935 (/ISS) P46935 (/ISS)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.	2	P46935 (/ISO) P46935 (/ISO)
Regulation of protein catabolic process at postsynapse, modulating synaptic transmission GO:0099576 Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.	2	P46935 (/ISO) P46935 (/ISO)
Negative regulation of systemic arterial blood pressure GO:0003085 The process that reduces the force with which blood travels through the systemic arterial circulatory system.	1	Q8CFI0 (/IMP)
Regulation of membrane depolarization GO:0003254 Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.	1	Q8CFI0 (/ISO)
Ubiquitin-dependent protein catabolic process GO:0006511 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.	1	Q8CFI0 (/ISO)
Protein monoubiquitination GO:0006513 Addition of a single ubiquitin group to a protein.	1	Q8CFI0 (/ISO)
Immune response GO:0006955 Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.	1	Q62940 (/IEP)
Response to salt stress GO:0009651 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.	1	Q8CFI0 (/IMP)
Response to metal ion GO:0010038 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.	1	Q8CFI0 (/ISO)
Positive regulation of sodium ion transport GO:0010765 Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	1	Q8CFI0 (/IGI)
Negative regulation of sodium ion transport GO:0010766 Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	1	Q8CFI0 (/IMP)
Negative regulation of sodium ion transport GO:0010766 Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	1	Q8CFI0 (/ISO)
Response to denervation involved in regulation of muscle adaptation GO:0014894 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation.	1	Q62940 (/IEP)
Negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.	1	Q62940 (/ISS)
Regulation of protein stability GO:0031647 Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.	1	Q8CFI0 (/ISO)
Regulation of protein stability GO:0031647 Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.	1	Q8CFI0 (/ISS)
Regulation of ion transmembrane transport GO:0034765 Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.	1	Q8CFI0 (/ISO)
Regulation of membrane potential GO:0042391 Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.	1	Q8CFI0 (/ISO)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.	1	Q8CFI0 (/ISO)
Regulation of dendrite morphogenesis GO:0048814 Any process that modulates the frequency, rate or extent of dendrite morphogenesis.	1	Q62940 (/IDA)
Regulation of membrane repolarization GO:0060306 Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative.	1	Q8CFI0 (/ISO)
Protein K63-linked ubiquitination GO:0070534 A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.	1	Q62940 (/IDA)
Protein K48-linked ubiquitination GO:0070936 A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.	1	Q8CFI0 (/ISO)
Ventricular cardiac muscle cell action potential GO:0086005 An action potential that occurs in a ventricular cardiac muscle cell.	1	F1LRN8 (/IMP)
Ventricular cardiac muscle cell action potential GO:0086005 An action potential that occurs in a ventricular cardiac muscle cell.	1	Q8CFI0 (/ISO)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.	1	Q62940 (/IDA)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.	1	Q62940 (/IMP)
Regulation of protein catabolic process at postsynapse, modulating synaptic transmission GO:0099576 Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.	1	Q62940 (/IDA)
Regulation of protein catabolic process at postsynapse, modulating synaptic transmission GO:0099576 Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.	1	Q62940 (/IMP)
Regulation of potassium ion transmembrane transporter activity GO:1901016 Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity.	1	Q8CFI0 (/ISO)
Negative regulation of potassium ion transmembrane transporter activity GO:1901017 Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity.	1	F1LRN8 (/IMP)
Negative regulation of potassium ion transmembrane transporter activity GO:1901017 Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity.	1	Q8CFI0 (/ISO)
Negative regulation of potassium ion transmembrane transport GO:1901380 Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport.	1	Q8CFI0 (/ISO)
Negative regulation of sodium ion transmembrane transport GO:1902306 Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport.	1	Q8CFI0 (/ISO)
Positive regulation of dendrite extension GO:1903861 Any process that activates or increases the frequency, rate or extent of dendrite extension.	1	Q8CFI0 (/ISO)
Negative regulation of protein localization to cell surface GO:2000009 Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface.	1	Q8CFI0 (/ISO)
Negative regulation of sodium ion transmembrane transporter activity GO:2000650 Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity.	1	Q8CFI0 (/ISO)
Regulation of bicellular tight junction assembly GO:2000810 Any process that modulates the frequency, rate or extent of tight junction assembly.	1	Q8CFI0 (/IDA)
Positive regulation of cation channel activity GO:2001259 Any process that activates or increases the frequency, rate or extent of cation channel activity.	1	Q8CFI0 (/IGI)
Positive regulation of caveolin-mediated endocytosis GO:2001288 Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis.	1	F1LRN8 (/IMP)
Positive regulation of caveolin-mediated endocytosis GO:2001288 Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis.	1	Q8CFI0 (/ISO)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Glutamatergic synapse GO:0098978 A synapse that uses glutamate as a neurotransmitter.	3	P46935 (/IDA) P46935 (/IDA) Q62940 (/IDA)
Glutamatergic synapse GO:0098978 A synapse that uses glutamate as a neurotransmitter.	3	P46935 (/IMP) P46935 (/IMP) Q62940 (/IMP)
Ubiquitin ligase complex GO:0000151 A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.	2	P46935 (/IPI) P46935 (/IPI)
Cytoplasm GO:0005737 All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	2	P46935 (/IDA) P46935 (/IDA)
Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	2	P46935 (/IDA) P46935 (/IDA)
Microvillus GO:0005902 Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.	2	P46935 (/ISO) P46935 (/ISO)
Membrane GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	2	P46935 (/IDA) P46935 (/IDA)
Dendritic spine GO:0043197 A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.	2	P46935 (/IDA) P46935 (/IDA)
Membrane raft GO:0045121 Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.	2	P46935 (/ISO) P46935 (/ISO)
Glutamatergic synapse GO:0098978 A synapse that uses glutamate as a neurotransmitter.	2	P46935 (/ISO) P46935 (/ISO)
Postsynaptic cytosol GO:0099524 The region of the cytosol consisting of all cytosol that is part of the postsynapse.	2	P46935 (/IDA) P46935 (/IDA)
Postsynaptic cytosol GO:0099524 The region of the cytosol consisting of all cytosol that is part of the postsynapse.	2	P46935 (/IMP) P46935 (/IMP)
Microvillus GO:0005902 Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.	1	Q62940 (/IDA)
Membrane raft GO:0045121 Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.	1	Q62940 (/IDA)

Functional Families

There are 19 GO terms relating to "molecular function"

There are 67 GO terms relating to "biological process"

There are 14 GO terms relating to "cellular component"