CATH Superfamily 2.20.70.10

Browse Functional Families

ID	Function Family (FunFam) Name	Total Sequences	Structure?	Structural Representative	PDB Sites?	Alignment Diversity (0-100)
1	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1	1717	3D	2zajA01	-	89.5
2	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform 1	1086		-	-	78.8
3	amyloid beta A4 precursor protein-binding family B member 2	1023	3D	2e45A01	-	92.7
4	dystrophin isoform X1	799	3D	1eg4A01	-	74.7
5	E3 ubiquitin-protein ligase	602	3D	5dwsC01	-	94.1
6	E3 ubiquitin-protein ligase NEDD4-like protein	568	3D	5ahtA01	-	75.6
7	E3 ubiquitin-protein ligase HECW2 isoform X1	559		-	-	76.7
8	E3 ubiquitin-protein ligase NEDD4-like protein	417		-	-	77.8
9	E3 ubiquitin-protein ligase	377		-	-	68.1
10	Transcription elongation regulator 1 CA150	353	3D	2dk7A00	-	79.2
11	E3 ubiquitin-protein ligase	350		-	-	68.5
12	transcriptional coactivator YAP1 isoform X2	323	3D	4rexA00	-	95.0
13	E3 ubiquitin-protein ligase HECW2 isoform X1	293		-	-	68.4
14	E3 ubiquitin-protein ligase SMURF1	281		-	-	64.0
15	Transcription elongation regulator 1 CA150	274		-	-	74.5
17	E3 ubiquitin-protein ligase	257	3D	2kxqA02	-	93.1
16	Transcription elongation regulator 1 CA150	256	3D	2ysiA01	-	59.5
18	DGCR8 microprocessor complex subunit	245	3D	3le4A00	-	87.7
19	Putative transcriptional coactivator YAP1	227	3D	2l4jA00	-	88.8
20	WW domain-containing adapter protein with coiled-coil isoform X1	223		-	-	65.6
21	E3 ubiquitin-protein ligase NEDD4	218		-	-	81.0
22	Rho GTPase activating protein 39	215		-	-	81.0
23	E3 ubiquitin-protein ligase	213		-	-	73.2
24	Rho GTPase activating protein 12	207		-	-	57.0
26	E3 ubiquitin-protein ligase	200		-	-	45.9
25	E3 ubiquitin-protein ligase NEDD4-like protein	200		-	-	34.1
27	pleckstrin homology domain-containing family A member 5 isoform X1	192		-	-	66.3
28	WW domain-containing protein	184		-	-	65.0
29	pre-mRNA-processing factor 40 homolog A isoform X1	177		-	-	58.3
30	Salvador family WW domain-containing protein 1	174		-	-	56.6
31	pre-mRNA-processing factor 40 homolog A isoform X1	173		-	-	58.8
32	WW domain containing oxidoreductase	169		-	-	70.5
33	Growth arrest specific 7	165		-	-	51.1
34	syntaxin-binding protein 4 isoform X1	165	3D	2ysgA01	-	81.1
35	Salvador homolog 1 Drosophila	163	3D	2ysbA01	-	74.4
36	Phosphorylated CTD-interacting factor 1	163	3D	2jx8A00	-	94.9
37	E3 ubiquitin-protein ligase nedd-4	156	3D	2ez5W01	-	78.2
46	Peptidyl-prolyl cis-trans isomerase	155	3D	5uy9A01	-	80.2
38	E3 ubiquitin-protein ligase	152		-	-	50.5
39	E3 ubiquitin-protein ligase	147		-	-	58.2
40	WW domain containing oxidoreductase	142		-	-	59.5
41	WW and C2 domain containing 1	131		-	-	76.7
43	Pleckstrin homology domain-containing, family A member 5	128		-	-	12.5
42	Histone-lysine N-methyltransferase	128		-	-	33.7
44	E3 ubiquitin-protein ligase SMURF2	127		-	-	78.6
45	E3 ubiquitin-protein ligase NEDD4-like	123		-	-	64.8
47	E3 ubiquitin-protein ligase	119		-	-	60.0
48	HECT, C2 and WW domain-containing E3 ubiquitin protein ligase 1	118		-	-	44.9
49	Transcription elongation regulator 1-like	116		-	-	97.7
50	pre-mRNA-processing factor 40 homolog B isoform X1	116		-	-	88.8
51	probable phosphoinositide phosphatase SAC9	100		-	-	77.9
53	E3 ubiquitin-protein ligase	92		-	-	72.8
52	pre-mRNA-processing factor 40 homolog B isoform X1	92		-	-	65.4
55	E3 ubiquitin-protein ligase NEDD4-like isoform X1	90		-	-	70.6
54	E3 ubiquitin-protein ligase SMURF1	90		-	-	31.5
56	Formin binding protein 4	82		-	-	72.6
58	Formin binding protein 4	80		-	-	46.1
57	FERM and PDZ domain-containing protein 4	80		-	-	58.3
59	pleckstrin homology domain-containing family A member 7	76		-	-	39.5
60	E3 ubiquitin-protein ligase	70		-	-	44.6
61	Rho GTPase activating protein 27	66		-	-	71.3
63	E3 ubiquitin-protein ligase NEDD4	62	3D	5cq2A02	-	87.2
62	IQ motif containing GTPase activating protein 1	61		-	-	56.3
64	rho GTPase-activating protein 9 isoform X2	58		-	-	74.0
65	Rho GTPase activating protein 27	58		-	-	66.4
66	Peptidyl-prolyl cis-trans isomerase	53	3D	2jv4A00	-	91.9
68	E3 ubiquitin-protein ligase	49		-	-	60.4
67	Pre-mRNA-processing protein 40C	49		-	-	75.8
69	Neural precursor cell expressed, developmentally down-regulated 4-like	46		-	-	34.8
70	Pre-mRNA-processing protein 40C	44		-	-	78.4
71	FERM domain Protein4.1-ezrin-radixin-moesin	42		-	-	64.8
72	Rho GTPase activating protein 12b	40		-	-	61.1
73	Rho GTPase activating protein 9	40		-	-	68.3
74	E3 ubiquitin-protein ligase	36		-	-	47.6
75	Pre-mRNA-processing protein 40A isoform A	34		-	-	79.4
76	Polyglutamine-binding protein 1	33		-	-	2.2
77	E3 ubiquitin-protein ligase	31		-	-	63.4
78	Formin binding protein FNB3	30		-	-	76.2
79	FCA gamma protein	30		-	-	63.2
80	E3 ubiquitin-protein ligase	29		-	-	39.9
84	E3 ubiquitin-protein ligase	28		-	-	67.7
82	Phosphorylated CTD-interacting factor	28		-	-	71.7
83	pre-mRNA-processing factor 40 homolog A isoform X3	28		-	-	62.5
81	PDZ domain-containing protein	28		-	-	60.4
85	Peptidyl-prolyl cis-trans isomerase	27		-	-	86.9
87	PArtner of DroSHa DRSH-1 interactor	26		-	-	76.4
86	NEDD4-like E3 ubiquitin-protein ligase WWP1	26		-	-	39.8
88	WW domain-binding protein 4	26	3D	2jxwA00	-	17.6
89	Blast:WW domain-containing adapter protein with coiled-coil	24		-	-	19.1
90	Formin binding protein FNB3	24		-	-	78.2
91	Flowering time control protein FCA isoform A	23		-	-	65.6
92	WW domain-binding protein 4	22		-	-	72.4
93	NEDD4-like E3 ubiquitin-protein ligase WWP1	22		-	-	47.7
94	transcriptional coactivator YAP1 isoform X1	21		-	-	16.4
96	E3 ubiquitin-protein ligase NEDD4 isoform X4	20		-	-	33.1
95	Pre-mRNA-processing factor 40	20		-	-	77.1
98	RNA-binding protein, putative	18		-	-	3.4
100	Pre-mRNA-processing protein 40A isoform A	18		-	-	41.3
99	E3 ubiquitin-protein ligase NEDD4	18		-	-	42.7
97	Dystrophin-1	18		-	-	9.5
101	Pre-mRNA-processing factor 40	17		-	-	79.4
102	Pre-mRNA-processing factor 40 homolog B	17		-	-	84.4
103	nudix hydrolase 23, chloroplastic-like	17		-	-	25.9
107	Chromosome 19, whole genome shotgun sequence	16		-	-	83.7
105	Pre-mRNA-processing factor 40, putative	16		-	-	56.2
104	Uncharacterized protein, isoform B	16		-	-	30.6
106	CUGBP Elav-like family member 2	16		-	-	11.7
110	CUGBP Elav-like family member 1	15		-	-	12.9
108	growth arrest-specific protein 7 isoform X2	15		-	-	22.2
111	E3 ubiquitin-protein ligase	15		-	-	40.1
109	Putative pre-mRNA-processing factor 40	15		-	-	8.5
112	Yorkie, isoform G	14		-	-	59.1
113	Clustered-asparagine-rich protein	14		-	-	0.0
114	Transcription elongation regulator	13		-	-	58.9
116	Transcription elongation regulator 1	12		-	-	26.5
115	WW domain-containing oxidoreductase isoform X4	12		-	-	15.4
117	Pre-mRNA-processing protein 40B	12		-	-	69.7
118	Transcription elongation regulator 1	12		-	-	55.6
119	WW_domain_containing_protein_-_putative	11		-	-	54.4
120	mRNA cap guanine-N7 methyltransferase	11		-	-	13.6
121	Transcription elongation regulator 1	11		-	-	74.3
122	Peptidyl-prolyl cis-trans isomerase	10		-	-	51.9
123	Uncharacterized protein	10		-	-	23.0
125	E3 ubiquitin-protein ligase Smurf1	9		-	-	45.6
124	DEAD box RNA helicase family protein	9		-	-	38.2
126	E3 ubiquitin-protein ligase	9		-	-	15.9
127	Pre-mRNA-processing protein 40A	8		-	-	74.0
128	WW domain-containing protein tag-325	8		-	-	28.0
130	Pre-mRNA-splicing factor dre4	8		-	-	79.6
132	U1 snRNP protein	8		-	-	43.8
129	Transcription factor TFIIE alpha subunit	8		-	-	66.7
135	U1 snRNP protein	8	3D	1o6wA02	-	0.0
131	WW domain-containing oxidoreductase	8		-	-	13.4
133	TransCription Elongation Regulator homolog	8		-	-	68.2
134	Uncharacterized protein, isoform C	8		-	-	65.1
136	Pre-mRNA-processing protein 40A	7		-	-	11.6
138	WW domain containing protein	7		-	-	0.0
137	Histone-lysine N-methyltransferase	7		-	-	70.5
140	GL18629	7		-	-	20.0
139	E3 ubiquitin-protein ligase Smurf1	7		-	-	13.5
142	TransCription Elongation Regulator homolog	6		-	-	19.1
143	Histone-lysine N-methyltransferase, H3 lysine-36 specific	6		-	-	75.2
141	Uncharacterized protein	6		-	-	8.6
153	Pre-mRNA-processing factor 40 homolog A-like Protein	5		-	-	72.4
144	Pre-mRNA-processing factor 40 homolog A	5		-	-	22.6
151	E3 ubiquitin-protein ligase	5		-	-	4.6
155	WW domain-containing protein A	5		-	-	49.6
154	Uncharacterized protein	5		-	-	92.4
147	Chromosome 19, whole genome shotgun sequence	5		-	-	74.4
149	Rho GTPase-activating protein 27	5		-	-	74.1
145	E3 ubiquitin-protein ligase	5		-	-	41.4
152	Pre-mRNA-processing factor 40 homolog A	5		-	-	83.0
150	E3 ubiquitin-protein ligase hecw-1	5		-	-	16.5
148	AFR317Cp	5		-	-	78.7
146	E3 ubiquitin-protein ligase	5		-	-	70.6
160	Pre-mRNA-splicing factor cwc2	4		-	-	50.9
170	Rho GTPase-activating protein 27	4		-	-	67.4
167	E3 ubiquitin-protein ligase	4		-	-	18.3
163	Histone-lysine N-methyltransferase	4		-	-	3.3
158	Predicted protein	4		-	-	50.7
165	Yes-associated protein homolog 1	4		-	-	26.2
156	Uncharacterized protein	4		-	-	28.6
168	Uncharacterized protein	4		-	-	39.2
161	E3 ubiquitin-protein ligase hecw-1	4		-	-	23.1
159	Predicted protein	4		-	-	77.1
162	Uncharacterized protein	4		-	-	12.9
169	Pre-mRNA processing protein, putative	4		-	-	48.1
157	E3 ubiquitin-protein ligase	4		-	-	64.5
166	WW domain containing protein, putative	4		-	-	0.0
164	WW_domain_containing_protein_-_putative	4		-	-	5.3
180	Pre-mRNA-processing factor 40	3		-	-	5.8
177	PQBP1 Polyglutamine tract-binding neurodegeneration protein	3		-	-	18.1
187	Uncharacterized protein	3		-	-	47.9
182	E3 ubiquitin-protein ligase	3		-	-	4.4
175	Uncharacterized protein	3		-	-	0.0
184	E3 ubiquitin-protein ligase	3		-	-	50.0
181	Reticulocyte-binding protein 2-like protein a	3		-	-	46.0
186	E3 ubiquitin-protein ligase	3		-	-	69.3
173	S-adenosyl-L-methionine-dependent methyltransferase superfamily protein	3		-	-	47.1
178	Histone-lysine N-methyltransferase	3		-	-	0.0
171	Uncharacterized protein	3		-	-	33.8
176	Histone-lysine N-methyltransferase	3		-	-	12.5
174	Predicted protein	3		-	-	57.6
183	E3 ubiquitin-protein ligase	3		-	-	0.0
172	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	3		-	-	35.9
179	YALI0C19404p	3		-	-	0.0
185	Peptidyl-prolyl cis-trans isomerase	3		-	-	74.7
211	Uncharacterized protein	2		-	-	8.3
236	Uncharacterized protein	2		-	-	45.3
218	Rho GTPase-activating protein 27,-like	2		-	-	0.0
234	Uncharacterized protein	2		-	-	42.0
193	Uncharacterized protein	2		-	-	46.9
189	MIP25048p	2		-	-	2.6
221	Putative mitochondrial protein	2		-	-	6.3
205	Uncharacterized protein	2		-	-	5.4
191	Predicted protein	2		-	-	47.9
212	Membrane-associated guanylate kinase, WW and PDZ domain-containing 3b	2		-	-	0.0
227	Uncharacterized protein	2		-	-	0.0
232	Uncharacterized protein	2		-	-	52.3
225	E3 ubiquitin-protein ligase	2		-	-	0.0
207	YALI0D02827p	2		-	-	0.0
198	transcriptional coactivator YAP1 isoform X2	2		-	-	0.0
202	mRNA cap guanine-N7 methyltransferase	2		-	-	12.8
230	Uncharacterized protein	2		-	-	38.1
214	YALI0D02827p	2		-	-	0.0
229	Predicted protein	2		-	-	0.0
222	E3 ubiquitin-protein ligase	2		-	-	48.5
217	Histone-lysine N-methyltransferase	2		-	-	0.0
209	WW domain containing protein, putative	2		-	-	0.0
210	Rho GTPase activating protein 27	2		-	-	11.1
219	Zygote-specific protein 3	2		-	-	0.0
196	Rho GTPase-activating protein 27,-like	2		-	-	0.0
206	Uncharacterized protein	2		-	-	0.0
194	Uncharacterized protein	2		-	-	50.1
220	WW domain-containing protein WWM1	2		-	-	47.0
226	WW domain-containing protein A	2		-	-	42.2
237	Uncharacterized protein	2		-	-	54.2
235	WW domain containing protein	2		-	-	44.9
213	Histone-lysine N-methyltransferase	2		-	-	0.0
200	Pre-mRNA-splicing factor URN1	2		-	-	0.0
197	Histone-lysine N-methyltransferase, H3 lysine-36 specific	2		-	-	0.0
224	E3 ubiquitin-protein ligase	2		-	-	2.8
192	Uncharacterized protein	2		-	-	48.7
215	WW domain containing protein, putative	2		-	-	0.0
233	Uncharacterized protein	2		-	-	55.8
208	Uncharacterized protein	2		-	-	0.0
199	Uncharacterized protein	2		-	-	4.4
195	Pasha/DGCR8	2		-	-	0.0
201	Uncharacterized protein	2		-	-	2.7
188	Peptidyl-prolyl cis-trans isomerase	2		-	-	26.3
190	Uncharacterized protein	2		-	-	40.2
231	Transcription elongation regulator, putative	2		-	-	40.3
203	Uncharacterized protein	2		-	-	8.1
204	Uncharacterized protein	2		-	-	0.0
228	Pre-mRNA-processing protein 40A	2		-	-	45.3
223	E3 ubiquitin-protein ligase	2		-	-	30.4
216	Uncharacterized protein	2		-	-	2.1
285	E3 ubiquitin-protein ligase	1		-	-	0.0
288	Uncharacterized protein	1		-	-	0.0
246	Uncharacterized protein	1		-	-	0.0
260	Predicted protein	1		-	-	0.0
272	Uncharacterized protein	1		-	-	0.0
287	Uncharacterized protein	1		-	-	0.0
262	Uncharacterized protein	1		-	-	0.0
264	Uncharacterized protein	1		-	-	0.0
255	Uncharacterized protein	1		-	-	0.0
274	RNA binding protein	1		-	-	0.0
250	Uncharacterized protein	1		-	-	0.0
278	WW domain protein	1		-	-	0.0
257	Uncharacterized protein	1		-	-	0.0
276	Predicted protein	1		-	-	0.0
259	Uncharacterized protein	1		-	-	0.0
249	Uncharacterized protein	1		-	-	0.0
240	Peptidyl-prolyl cis-trans isomerase	1		-	-	0.0
239	Peptidyl-prolyl cis-trans isomerase	1		-	-	0.0
281	Predicted protein	1		-	-	0.0
269	Rho GTPase activating protein 27	1		-	-	0.0
284	Predicted protein	1		-	-	0.0
247	Histone-lysine N-methyltransferase, H3 lysine-36 specific	1		-	-	0.0
289	Pre-mRNA-processing protein 40A	1		-	-	0.0
290	Uncharacterized protein	1		-	-	0.0
252	Uncharacterized protein	1		-	-	0.0
283	Uncharacterized protein	1		-	-	0.0
271	Histone-lysine N-methyltransferase	1		-	-	0.0
242	Peptidyl-prolyl cis-trans isomerase	1		-	-	0.0
244	ADR159Cp	1		-	-	0.0
286	Neural cell expressed, developmentally down-regulated 4-like	1		-	-	0.0
254	Uncharacterized protein	1		-	-	0.0
265	Uncharacterized protein	1		-	-	0.0
275	Uncharacterized protein	1		-	-	0.0
251	Uncharacterized protein	1		-	-	0.0
279	Uncharacterized protein	1		-	-	0.0
256	Predicted protein	1		-	-	0.0
263	Predicted protein	1		-	-	0.0
245	Chromosome 9, whole genome shotgun sequence	1		-	-	0.0
267	E3 ubiquitin-protein ligase HECW2-like Protein	1		-	-	0.0
292	Uncharacterized protein	1		-	-	0.0
291	Uncharacterized protein	1		-	-	0.0
241	Peptidyl-prolyl cis-trans isomerase	1		-	-	0.0
280	Uncharacterized protein	1		-	-	0.0
273	Rho GTPase activating protein 27, like	1		-	-	0.0
270	Uncharacterized protein	1		-	-	0.0
266	Uncharacterized protein	1		-	-	0.0
243	Uncharacterized protein	1		-	-	0.0
261	Predicted protein	1		-	-	0.0
268	Rho GTPase-activating protein 27	1		-	-	0.0
282	Uncharacterized protein	1		-	-	0.0
238	Peptidyl-prolyl cis-trans isomerase	1		-	-	0.0
253	Membrane associated guanylate kinase, WW and PDZ domain containing 3	1		-	-	0.0
277	Uncharacterized protein	1		-	-	0.0
258	Uncharacterized protein	1		-	-	0.0
248	Uncharacterized protein	1		-	-	0.0