The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Cystine-knot cytokines
".
FunFam 17: Platelet derived growth factor subunit A
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 20 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Platelet-derived growth factor receptor binding GO:0005161
Interacting selectively and non-covalently with the platelet-derived growth factor receptor.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Platelet-derived growth factor receptor binding GO:0005161
Interacting selectively and non-covalently with the platelet-derived growth factor receptor.
|
1 | P04085 (/IDA) |
|
Platelet-derived growth factor receptor binding GO:0005161
Interacting selectively and non-covalently with the platelet-derived growth factor receptor.
|
1 | P04085 (/IPI) |
|
Platelet-derived growth factor receptor binding GO:0005161
Interacting selectively and non-covalently with the platelet-derived growth factor receptor.
|
1 | P20033 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P04085 (/IPI) |
|
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
1 | P04085 (/IDA) |
|
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
1 | P20033 (/ISO) |
Showing 1 to 10 of 20 entries
There are 96 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Negative regulation of phosphatidylinositol biosynthetic process GO:0010512
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Negative regulation of platelet activation GO:0010544
Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Regulation of smooth muscle cell migration GO:0014910
Any process that modulates the frequency, rate or extent of smooth muscle cell migration.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Positive regulation of protein autophosphorylation GO:0031954
Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793
Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration as a result of the series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Positive regulation of MAP kinase activity GO:0043406
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
Showing 1 to 10 of 96 entries
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
4 | P20033 (/ISS) P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
3 | P28576 (/ISS) P34007 (/ISS) Q2KJ15 (/ISS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | P04085 (/IDA) P20033 (/IDA) |
|
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
|
2 | P04085 (/ISS) P28576 (/ISS) |
|
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
|
1 | P04085 (/TAS) |
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | P04085 (/TAS) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P20033 (/ISO) |
|
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
1 | P04085 (/TAS) |
|
Golgi lumen GO:0005796
The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks.
|
1 | P04085 (/TAS) |
|
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
|
1 | P20033 (/IDA) |
Showing 1 to 10 of 13 entries
