The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cystine-knot cytokines
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1324
3D
4mplA00 - 98.5
2
736
3D
6ffyC00 - 94.0
3
680
3D
1m4uL00 - 85.4
4
624
3D
4kv5D00 - 92.7
5
578
3D
5hlzF00 - 90.2
6
484
3D
3sekB00 - 93.7
7
448
3D
4mqwH00 - 99.0
9
344
3D
6d3oB00 - 81.8
8
319
3D
2qcqB00 - 88.4
11
224
3D
4mqwG00 - 83.5
10
224 - - 84.3
12
Predicted
206 - - 97.0
13
185
3D
5aejD00 - 61.1
15
179
3D
3fubD00 - 72.7
14
176
3D
1m4uA01 - 89.4
16
140
3D
4x1jA00 - 43.4
17
139
3D
3mjkA00 - 72.0
18
138 - - 95.9
19
130 - - 20.4
22
121
3D
5bqeB00 - 52.7
20
120 - - 69.6
21
109 - - 71.3
23
99 - - 70.9
24
93 - - 73.3
25
88 - - 72.8
26
85
3D
4n1dA00 - 83.9
30
85
3D
2xacB00 - 92.4
38
85
3D
5nanF00 - 86.5
32
84
3D
2gyzA00 - 82.6
27
83 - - 67.4
28
82 - - 80.0
29
80 - - 74.7
31
79
3D
1rv6W00 - 75.1
33
69 - - 88.4
34
64 - - 36.2
37
63
3D
5nmzD00 - 85.4
35
61 - - 91.5
36
58
3D
2kd3A00 - 33.0
39
49 - - 89.1
40
44 - - 56.6
41
38 - - 70.4
42
Xenopus laevis
38 - - 76.4
43
29 - - 38.6
44
25 - - 60.3
45
24 - - 78.4
56
22
3D
4lxsK00 - 93.1
46
19 - - 32.7
47
19 - - 83.9
48
18 - - 70.5
51
18 - - 82.0
53
18 - - 81.6
49
18 - - 93.2
50
18 - - 35.7
52
18 - - 74.4
54
16 - - 37.2
55
15 - - 80.4
57
13 - - 31.3
58
11 - - 78.9
60
10 - - 3.5
61
10 - - 69.2
59
10 - - 54.0
62
9 - - 15.7
65
8 - - 2.5
63
8 - - 24.9
64
8 - - 19.9
69
7 - - 14.0
67
7 - - 13.6
68
7 - - 18.3
66
beta polypeptide
7 - - 39.4
71
6 - - 5.7
72
6 - - 88.3
70
6 - - 10.6
74
5 - - 15.6
75
5 - - 89.1
73
5 - - 10.0
78
4 - - 33.8
80
4 - - 6.9
82
4 - - 9.6
76
4 - - 4.7
84
4 - - 0.0
103
4
3D
1reuA00 - 39.7
85
4 - - 8.0
87
4 - - 13.1
81
4 - - 4.4
77
4 - - 32.2
79
4 - - 74.5
83
4 - - 2.4
86
4 - - 5.8
88
4 - - 68.0
89
3 - - 15.4
92
3 - - 13.1
90
3 - - 7.0
96
3 - - 0.0
94
3 - - 17.1
98
3 - - 0.0
91
3 - - 9.6
93
3 - - 11.4
95
3 - - 36.4
97
3 - - 0.0
112
2 - - 0.0
105
2 - - 43.0
129
2 - - 0.0
124
2 - - 0.0
99
2 - - 4.6
131
2 - - 0.0
119
2 - - 0.0
110
2 - - 0.0
126
2 - - 0.0
133
Fragment
2 - - 42.2
117
2 - - 0.0
135
2 - - 13.1
109
2 - - 0.0
121
2 - - 0.9
107
2 - - 2.0
130
2 - - 0.0
115
2 - - 0.0
123
2 - - 10.4
128
2 - - 4.5
132
2 - - 0.0
111
2 - - 3.7
113
2 - - 0.0
102
2 - - 38.0
125
2 - - 1.9
118
2 - - 0.0
100
2 - - 32.4
134
2 - - 41.5
127
2 - - 0.0
101
2 - - 34.6
116
2 - - 0.0
108
2 - - 2.1
120
2 - - 1.5
106
2 - - 39.7
122
2 - - 1.9
114
2 - - 0.0
104
2 - - 38.9
170
1 - - 0.0
165
1 - - 0.0
168
1 - - 0.0
148
1 - - 0.0
157
1 - - 0.0
179
1 - - 0.0
141
1 - - 0.0
163
1 - - 0.0
176
1 - - 0.0
143
1 - - 0.0
137
1 - - 0.0
175
1 - - 0.0
154
1 - - 0.0
147
1 - - 0.0
145
1 - - 0.0
152
1 - - 0.0
160
1 - - 0.0
167
1 - - 0.0
140
1 - - 0.0
150
1 - - 0.0
159
1 - - 0.0
162
1 - - 0.0
169
1 - - 0.0
172
1 - - 0.0
142
1 - - 0.0
158
1 - - 0.0
149
1 - - 0.0
139
1 - - 0.0
178
1 - - 0.0
144
1 - - 0.0
177
1 - - 0.0
156
1 - - 0.0
171
1 - - 0.0
166
1 - - 0.0
153
1 - - 0.0
136
1 - - 0.0
155
1 - - 0.0
161
1 - - 0.0
174
1 - - 0.0
146
1 - - 0.0
164
1 - - 0.0
151
1 - - 0.0
138
1 - - 0.0
173
1 - - 0.0
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