The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cystine-knot cytokines
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Neuroblastoma suppressor of tumorigenicity 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P41271 (/IPI) P41271 (/IPI) P41271 (/IPI) P41271 (/IPI) P41271 (/IPI) Q61477 (/IPI)
Morphogen activity GO:0016015
Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient.
5 P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS)
BMP binding GO:0036122
Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family.
5 P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
5 P41271 (/IMP) P41271 (/IMP) P41271 (/IMP) P41271 (/IMP) P41271 (/IMP)
Morphogen activity GO:0016015
Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient.
1 Q61477 (/IDA)
BMP binding GO:0036122
Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family.
1 Q61477 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q61477 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
6 P41271 (/IDA) P41271 (/IDA) P41271 (/IDA) P41271 (/IDA) P41271 (/IDA) Q61477 (/IDA)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
5 P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
5 P41271 (/IMP) P41271 (/IMP) P41271 (/IMP) P41271 (/IMP) P41271 (/IMP)
Sequestering of BMP in extracellular matrix GO:0035582
Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
5 P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS)
Sequestering of BMP from receptor via BMP binding GO:0038098
Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor.
5 P41271 (/IDA) P41271 (/IDA) P41271 (/IDA) P41271 (/IDA) P41271 (/IDA)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
5 P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS)
Determination of dorsal identity GO:0048263
Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
5 P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
5 P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS)
Negative regulation of monocyte chemotaxis GO:0090027
Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.
5 P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS) P41271 (/ISS)
Determination of dorsal identity GO:0048263
Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
3 O73753 (/IMP) O73753 (/IMP) Q61477 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q61477 (/IMP)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
1 Q06880 (/ISS)
Sequestering of BMP in extracellular matrix GO:0035582
Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
1 Q61477 (/IDA)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 Q61477 (/IDA)
Semicircular canal morphogenesis GO:0048752
The process in which the anatomical structures of the semicircular canals are generated and organized.
1 Q90YC9 (/IMP)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
1 Q61477 (/IDA)
Semicircular canal development GO:0060872
The progression of the semicircular canal from its initial formation to the mature structure.
1 Q6NZ13 (/IMP)
Semicircular canal formation GO:0060876
The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes.
1 Q6NZ13 (/IMP)
Negative regulation of monocyte chemotaxis GO:0090027
Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.
1 Q61477 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
7 O73753 (/IDA) O73753 (/IDA) P41271 (/IDA) P41271 (/IDA) P41271 (/IDA) P41271 (/IDA) P41271 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
5 P41271 (/IC) P41271 (/IC) P41271 (/IC) P41271 (/IC) P41271 (/IC)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q06880 (/ISS) Q61477 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q61477 (/ISO)
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